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- Forsberg, S, et al.
(author)
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Determination of Gibbs energies of formation of CaFe2O4 and Ca2Fe2O5 from solid-state EMF measurements using CaF2 as solid electrolyte
- 2002
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In: Metallurgical and Materials Transactions B-Process Metallurgy and Materials Processing Science. - 1073-5615. ; 33:3, s. 385-92
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Journal article (peer-reviewed)abstract
- The standard Gibbs energy change for the reactions CaO + Fe2O3 --> CaFe2O4 and 2 CaO + Fe2O3 --> Ca2Fe2O5 has been determined from solid-state electromotive force (emf) measurements, using CaF2 as solid electrolyte. The temperature dependence of the standard Gibbs energies of formation from the elements is represented by the equationsDelta(f)G(o)(CaFe2O4) = - 1448.4 x 10(3) + 128.0 T + 27.95 T In (T) (+/- 1800) J mol(-1)1030 < T/K < 1280Delta(f)G(o)(Ca2Fe2O5) = -2049.9 x 10(3) - 12.84 T + 55.91 T In (T) (+/-2800) J mol(-1)1140 < T/K < 1340By applying a "third-law" analysis of the experimental data, the standard enthalpy of formation of CaFe2O4 from constituent oxides at 298 K was evaluated as DeltaH(298)(o)(CaFe2O4) = - 17.5 +/- 0.4 kJ mol(-1). A description of the developed apparatus for emf measurements is given.
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- Forsberg, Rebecca, et al.
(author)
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Survivors' experiences from a train crash
- 2011
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In: International Journal of Qualitative Studies on Health and Well-being. - Stockholm : Co-Action Publishing. - 1748-2623 .- 1748-2631. ; 6:4, s. 8401-
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Journal article (peer-reviewed)abstract
- Rarely described are people's lived experiences from severe injury events such as train crashes. The number of train crashes named disasters with ≥10 killed and/or ≥100 nonfatally injured grows globally and the trend shows that more people survive these disasters today than did so in the past. This results in an increased number of survivors needing care. The aim of the study was to explore survivors' experiences from a train crash. Narrative interviews were performed with 14 passengers 4 years after a train crash event. Qualitative content analysis was used to analyse the interviews. Experiences were captured in three main themes: (1) Living in the mode of existential threat describes how the survivors first lost control, then were thrown into a state of unimaginable chaos as they faced death. (2) Dealing with the unthinkable described how survivors restored control, the central role of others, and the importance of reconstructing the event to move forward in their processing. (3) Having cheated death shows how some became shackled by their history, whereas others overcame the haunting of unforgettable memories. Furthermore, the result shows how all experienced a second chance in life. Experiencing a train crash meant that the passengers experienced severe vulnerability and a threat to life and interdependence turned out to play a crucial role. Focusing on helping other passengers on site was one way to regain the loss of control and kept the chaos at bay. Family, friends, and fellow passengers turned out to be extremely important during the recovery process why such closeness should be promoted and facilitated.
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- Forsberg, Sune
(author)
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Comatose patients in the non-traumatic emergency room : clinical findings, etiologies and prognosis
- 2012
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Doctoral thesis (other academic/artistic)abstract
- A reduced level of consciousness is an acute and life threatening condition that requires a rapid and structured management in order to maintain life and brain function. Unconscious patients admitted to the non-traumatic emergency room thus present a major challenge to physicians. The scientific knowledge in the field is limited. The aims of this thesis were to improve the knowledge of underlying etiologies to coma and their short and long term prognosis, and to search for clinical tools to facilitate the diagnostic procedure. The findings reported in this thesis are mainly based on a cohort of prospectively included patients admitted unconscious to hospital during the years 2003-2005. A complementary cohort consists of poisoned patients consecutively admitted to hospital during the years 2009 through 2010. Poisoning was the most common cause of unconsciousness in the non-surgical emergency room (38%) and young age was a strong predictor of this condition (80% of the comatose patients with an age below 40 consisted of poisonings). Around one third of all hospitalized poisonings had a pronounced central nervous system depression on admission. The mortality rate among poisonings presenting unresponsive was found to be at least five times higher than the overall mortality from acute poisoning. The acute prognosis in patients presenting comatose to the emergency room was shown to be serious and dependent on both coma etiology and depth of coma. The overall hospital mortality was 26.5%. Long term prognosis among he hospital survivors was strongly correlated to the coma etiology, with 2-year mortality rates ranging from 11.5% for poisonings to 83% for malignancies, but was not influenced by the initial Glasgow coma scale score. Overall, the prognosis was much more favourable for the coma etiologies poisoning and epilepsy. A composite of age, systolic blood pressure and results of a routine neurological examination could be shown to validly discriminate between the two underlying causes of consciousness disturbances, namely those of metabolic or focal origin. From the data obtained, the following diagnostic algorithm may be formulated: If a patient is younger than 51 years of age, and his or hers systolic blood pressure on admission is below 151 mm Hg, and no neurological findings indicative of a discrete lesion within the central nervous system is present, then the statistical probability of an underlying metabolic coma is 96%. If the algorithm presented above were to be applied routinely in the emergency room, the numbers of emergency CT scans could be considerably reduced. Consequently, other potentially life saving procedures would achieve a higher priority in the emergency room.
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- Forsberg, Sofi, et al.
(author)
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Comparison of growth-inhibitory agents by fluorescence imaging of human skin re-epithelialization in vitro
- 2006
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In: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 0001-5555 .- 1651-2057. ; 86:4, s. 292-299
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Journal article (peer-reviewed)abstract
- Drug screening procedures should preferably utilize experimental settings mimicking the in vivo situation. The aim of this study was to evaluate a skin explant model as a tool to identify topical agents with anti-proliferative properties in human epidermis. Re-epithelialization was initiated from a skin punch biopsy explanted onto de-epidermized dermis and cultured at the air-liquid interface in the presence of the epidermal growth factor receptor kinase inhibitor PKI166, tacrolimus or established topical anti-psoriatic drugs: betamethasone, calcipotriol, dithranol and tazarotene. Neo-epidermal extension was traced by fluorescence microscopy prior to histomorphometric analysis. PKI166 at 1 mu M decreased the mean radial outgrowth rate (-19%), frequency of BrdU-positive (-37%) and laminin 5-positive (-45%) cells, indicating reduced proliferation and migration of neo-epidermal keratinocytes. However, the papillomatosis index and epithelial thickness were not significantly affected. Calcipotriol at 1 mu M had a similar effect on the outgrowth rate (-15%) and fraction of laminin 5-stained keratinocytes (-40%). Furthermore, calcipotriol significantly reduced mean neo-epidermal thickness. Equimolar concentrations of the other test compounds had no apparent effect on histology or outgrowth parameters. This study exemplifies the versatility of combined dynamic and morphological analysis and emphasizes the potential of epidermal growth factor receptor-directed inhibition in hyperproliferative disorders of the epidermis.
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- Forsberg, Simon K. G., et al.
(author)
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Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast
- 2017
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 49:4, s. 497-503
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Journal article (peer-reviewed)abstract
- Experiments in model organisms report abundant genetic interactions underlying biologically important traits, whereas quantitative genetics theory predicts, and data support, the notion that most genetic variance in populations is additive. Here we describe networks of capacitating genetic interactions that contribute to quantitative trait variation in a large yeast intercross population. The additive variance explained by individual loci in a network is highly dependent on the allele frequencies of the interacting loci. Modeling of phenotypes for multilocus genotype classes in the epistatic networks is often improved by accounting for the interactions. We discuss the implications of these results for attempts to dissect genetic architectures and to predict individual phenotypes and long-term responses to selection.
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