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Träfflista för sökning "(L773:1097 4199) srt2:(1988-1989)"

Search: (L773:1097 4199) > (1988-1989)

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  • Ernfors, P, et al. (author)
  • Developmental and regional expression of beta-nerve growth factor receptor mRNA in the chick and rat.
  • 1988
  • In: Neuron. - 0896-6273 .- 1097-4199. ; 1:10, s. 983-96
  • Journal article (peer-reviewed)abstract
    • Hybridization probes from the transmembrane region of the chick NGF receptor (NGF-R) that show high homology with the rat NGF-R were used to demonstrate an abundant 4.5 kb NGF-R mRNA in the chick embryo at E3.5. The level remained high until E12 but decreased to adult levels by E18. The highest levels at E8 were in spinal cord, bursa of Fabricius, gizzard, femoralis muscle, and skin. In situ hybridization to E7 embryos showed high expression of the NGF-R gene in spinal cord, particularly the lateral motor column, and in dorsal root, sympathetic, and nodose ganglia. NGF-R mRNA expression was observed throughout brain development and in all regions of the adult brain, with high levels in cerebellum and septum. Lymphoid tissues of chick and rat also expressed the receptor. The complex and widespread expression of NGF-R mRNA in areas not known to be NGF targets suggests broader functions for NGF.
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  • Result 1-1 of 1
Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Ernfors, P (1)
Persson, H (1)
Ebendal, T (1)
Hallböök, F (1)
Shooter, E M (1)
Radeke, M J (1)
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Misko, T P (1)
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University
Uppsala University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
1988 (1)

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