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1.	Alm, PS, et al. (author) Grandpaternal high-fat diet transgenerationaly impacts the skeletal muscle unfolded protein response in F2-female offspring 2016 In: DIABETOLOGIA. - 0012-186X. ; 59, s. S170-S170 Conference paper (other academic/artistic)
2.	Alm, PS, et al. (author) Maternal obesity legacy: exercise it away! 2016 In: Diabetologia. - : Springer Science and Business Media LLC. - 1432-0428 .- 0012-186X. ; 59:1, s. 5-8 Journal article (peer-reviewed)
3.	Barbosa, TD, et al. (author) High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring 2016 In: Molecular metabolism. - : Elsevier BV. - 2212-8778. ; 5:3, s. 184-197 Journal article (peer-reviewed)
4.	Jiang, LQ, et al. (author) Diacylglycerol kinase-δ regulates AMPK signaling, lipid metabolism, and skeletal muscle energetics 2016 In: American journal of physiology. Endocrinology and metabolism. - : American Physiological Society. - 1522-1555 .- 0193-1849. ; 310:1, s. E51-E60 Journal article (peer-reviewed)abstract Decrease of AMPK-related signal transduction and insufficient lipid oxidation contributes to the pathogenesis of obesity and type 2 diabetes. Previously, we identified that diacylglycerol kinase-δ (DGKδ), an enzyme involved in triglyceride biosynthesis, is reduced in skeletal muscle from type 2 diabetic patients. Here, we tested the hypothesis that DGKδ plays a role in maintaining appropriate AMPK action in skeletal muscle and energetic aspects of contraction. Voluntary running activity was reduced in DGKδ+/−mice, but glycogen content and mitochondrial markers were unaltered, suggesting that DGKδ deficiency affects skeletal muscle energetics but not mitochondrial protein abundance. We next determined the role of DGKδ in AMPK-related signal transduction and lipid metabolism in isolated skeletal muscle. AMPK activation and signaling were reduced in DGKδ+/−mice, concomitant with impaired lipid oxidation and elevated incorporation of free fatty acids into triglycerides. Strikingly, DGKδ deficiency impaired work performance, as evident by altered force production and relaxation dynamics in response to repeated contractions. In conclusion, DGKδ deficiency impairs AMPK signaling and lipid metabolism, thereby highlighting the deleterious role of excessive lipid metabolites in the development of peripheral insulin resistance and type 2 diabetes pathogenesis. DGKδ deficiency also influences skeletal muscle energetics, which may lead to low physical activity levels in type 2 diabetes.

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Type of publication: journal article (3); conference paper (1)

Type of content: peer-reviewed (3); other academic/artistic (1)

Author/Editor: Barbosa, TD (4); Krook, A (3); Zierath, JR (3); Alm, PS (3); Massart, J. (2); Gupta, S. (1); show more...; Chibalin, AV (1); Barres, R (1); Osler, ME (1); Lofgren, L (1); Rasmussen, M. (1); Barrs, R (1); Ingerslev, LR (1); Versteyhe, S (1); Donkin, I (1); Sjogren, R (1); Mudry, JM (1); Vetterli, L (1); Jiang, LQ (1); Deshmukh, AS (1); Duque-Guimaraes, DE (1); Ozilgen, A (1); show less...

University: Karolinska Institutet (4)

Language: English (4)

Year: 2016 (4)Undo refine

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