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Träfflista för sökning "(db:Swepub) srt2:(2010-2011) conttype:(popularscientific) "

Search: (db:Swepub) srt2:(2010-2011) conttype:(popularscientific)

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  • Aahlin, Kristofer, et al. (author)
  • Preparation of 1-(4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)benzoyl)piperazine derivatives as glycogen synthase kinase 3 inhibitors.
  • 2011
  • Patent (pop. science, debate, etc.)abstract
    • Title compds. I [R1 = H or Me], and their pharmaceutically acceptable salts, are prepd. and disclosed as glycogen synthase kinase 3 (GSK3) inhibitors. Thus, e.g., II was prepd. by cyclization of 3-amino-N-(4-hydroxypyridin-3-yl)pyrazine-2-carboxamide (prepn. given) to get intermediate 3-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-amine, which underwent bromination followed by Suzuki reaction with (4-methylpiperazin-1-yl)(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanone. Compds. of the invention were tested for their selective inhibitory activity of GSK3β, e.g., II exhibited Ki value of 2.3 nM. The invention compds. are useful for the treatment of cognitive disorders, diabetes, cancer, etc. [on SciFinder(R)]
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  • Abani, Chris (author)
  • Meet Chris Abani
  • 2010
  • Other publication (pop. science, debate, etc.)abstract
    • The poet and author Chris Abani talks about alienation and poetry.
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Skapa referenser, mejla, bekava och länka
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Natural sciences (457)
Medical and Health Sciences (295)

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