SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "L773:0028 3908 "

Search: L773:0028 3908

  • Result 1-10 of 179
Sort/group result
   
EnumerationReferenceCoverFind
1.
  • Arslan, G, et al. (author)
  • P2Y receptors contribute to ATP-induced increases in intracellular calcium in differentiated but not undifferentiated PC12 cells
  • 2000
  • In: Neuropharmacology. - 1873-7064 .- 0028-3908. ; 39:3, s. 482-496
  • Journal article (peer-reviewed)abstract
    • ATP-induced Ca2+ transients were examined in individual PC12 cells of a well defined clone, before and after treatment with nerve growth factor (NGF) to induce a neurone-like phenotype. Using reverse transcriptase PCR these cells were found to express mRNA for several P2 receptors. In undifferentiated cells the ATP-induced Ca2+ response was entirely dependent on Ca2+ influx, could not be mimicked by UTP, alpha,beta-methylene ATP or dibenzoyl ATP or be blocked by pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS). ATP had no significant effect on levels of cyclic AMP or inositol 1,4,5-trisphosphate (InsP3). These results suggest that in undifferentiated PC12 cells ATP mainly acts on a P2X receptor, possibly the P2X4 subtype. After treatment with NGF for 7 days the ATP response was increased and partially sensitive to PPADS. A component of the ATP-induced Ca2+ increase was due to mobilisation of intracellular Ca2+ stores and another to capacitative Ca2+ entry. UTP caused an increase in intracellular Ca2+, and InsP3 formation could be stimulated by ATP and UTP. ATP also caused a small increase in cyclic AMP, but this was abolished in the presence of indomethacin. Thus, after NGF treatment ATP acts partially via a P2Y receptor, possibly the P2Y2 subtype.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-10 of 179
Type of publication
journal article (173)
research review (5)
conference paper (1)
Type of content
peer-reviewed (176)
other academic/artistic (3)
Author/Editor
Fuxe, K (17)
Svenningsson, P (12)
Adermark, Louise, 19 ... (10)
Fredholm, BB (9)
Ogren, SO (7)
Söderpalm, Bo, 1959 (7)
show more...
Ericson, Mia, 1970 (6)
Mathe, AA (5)
Halldin, C (5)
Borroto-Escuela, DO (5)
Narvaez, JA (5)
Erhardt, S (4)
Johansson, B (3)
Schiöth, Helgi B. (3)
Dickson, Suzanne L., ... (3)
Jerlhag, Elisabeth, ... (3)
Nyberg, Fred (3)
Jonsson, Susanne, 19 ... (3)
Varnas, K (3)
Girault, JA (3)
Agnati, LF (3)
Franco, R (3)
Marcellino, D (3)
Zhu, J. (2)
Lindholm, Dan (2)
Winblad, B (2)
Levi, M (2)
Sandberg, Mats, 1953 (2)
Zou, LP (2)
Wahren, B (2)
Sehlin, Dag, 1976- (2)
Ingelsson, Martin (2)
Aden, U (2)
Morud, Julia, 1984 (2)
Lagström, Oona (2)
Lovinger, David M (2)
Heilig, Markus (2)
Hokfelt, T (2)
Hammarlund-Udenaes, ... (2)
Goiny, M (2)
Antonelli, T (2)
Ferraro, L (2)
Kehr, J (2)
Misane, I (2)
Ceccatelli, S (2)
Ahlenius, S (2)
Langstrom, B (2)
Bergström, M (2)
Nag, S (2)
Gulyas, B (2)
show less...
University
Karolinska Institutet (114)
Uppsala University (28)
University of Gothenburg (27)
Lund University (9)
Linköping University (6)
Umeå University (1)
show more...
Royal Institute of Technology (1)
Chalmers University of Technology (1)
Linnaeus University (1)
show less...
Language
English (179)
Research subject (UKÄ/SCB)
Medical and Health Sciences (62)
Social Sciences (1)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view