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Träfflista för sökning "L773:0036 8075 OR L773:1095 9203 ;lar1:(gu);lar1:(liu);pers:(Nätt Daniel)"

Search: L773:0036 8075 OR L773:1095 9203 > University of Gothenburg > Linköping University > Nätt Daniel

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  • Barbier, Estelle, et al. (author)
  • A molecular mechanism for choosing alcohol over an alternative reward
  • 2018
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 360:6395
  • Journal article (peer-reviewed)abstract
    • Alcohol addiction leads to increased choice of alcohol over healthy rewards. We established an exclusive choice procedure in which similar to 15% of outbred rats chose alcohol over a high-value reward. These animals displayed addiction-like traits, including high motivation to obtain alcohol and pursuit of this drug despite adverse consequences. Expression of the g-aminobutyric acid (GABA) transporter GAT-3 was selectively decreased within the amygdala of alcohol-choosing rats, whereas a knockdown of this transcript reversed choice preference of rats that originally chose a sweet solution over alcohol. GAT-3 expression was selectively decreased in the central amygdala of alcohol-dependent people compared to those who died of unrelated causes. Impaired GABA clearance within the amygdala contributes to alcohol addiction, appears to translate between species, and may offer targets for new pharmacotherapies for treating this disorder.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Adermark, Louise, 19 ... (1)
Licheri, Valentina (1)
Heilig, Markus (1)
Mayfield, R D (1)
Augier, Eric (1)
Augier, Gaelle (1)
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Barbier, Estelle (1)
Dulman, R. S. (1)
Domi, Esi (1)
Barchiesi, Riccardo (1)
Farris, S. (1)
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University
University of Gothenburg  (1)Undo refine
Linköping University  (1)Undo refine
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2018 (1)

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