| 1. |
- Volpe, Giovanni, 1979, et al.
(author)
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Roadmap for optical tweezers
- 2023
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In: Journal of Physics-Photonics. - : IOP Publishing. - 2515-7647. ; 5:2
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Journal article (peer-reviewed)abstract
- Optical tweezers are tools made of light that enable contactless pushing, trapping, and manipulation of objects, ranging from atoms to space light sails. Since the pioneering work by Arthur Ashkin in the 1970s, optical tweezers have evolved into sophisticated instruments and have been employed in a broad range of applications in the life sciences, physics, and engineering. These include accurate force and torque measurement at the femtonewton level, microrheology of complex fluids, single micro- and nano-particle spectroscopy, single-cell analysis, and statistical-physics experiments. This roadmap provides insights into current investigations involving optical forces and optical tweezers from their theoretical foundations to designs and setups. It also offers perspectives for applications to a wide range of research fields, from biophysics to space exploration.
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| 2. |
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| 3. |
- Adiels, Lars, 1952-, et al.
(author)
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Test of CP violation with K0 and K‾0 at LEAR
- 1985
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In: Physics with antiprotons at LEAR in the ACOL era. - Gif sur Yvette : Editions Frontières. - 2863320351 ; , s. 467-482
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Conference paper (other academic/artistic)
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| 4. |
- Adiels, L., et al.
(author)
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Experimental determination of the branching ratios proton-antiproton -> 2pi0, pi0γ and γγ at rest
- 1987
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In: Zeitschrift für Physik C Particles and Fields. - 0170-9739. ; 35:1, s. 15-19
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Journal article (peer-reviewed)abstract
- The branching ratios of Mathematical expression annihilations into the neutral final states 2π0, π0γ, and 2γ are measured by stopping antiprotons in liquid hydrogen. They are Mathematical expression, Mathematical expression, and Bγγ<1.7×10-6 (95% c.l.). © 1987 Springer-Verlag.
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| 5. |
- Adiels, Lars, et al.
(author)
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Experimental study of the inclusive η-spectrum from proton-antiproton annihilations at rest in liquid hydrogen
- 1989
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In: Zeitschrift für Physik C Particles and Fields. - 0170-9739 .- 1431-5858. ; 42, s. 49-58
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Journal article (peer-reviewed)abstract
- The inclusive η-momentum spectrum from Mathematical expression annihilations at rest in liquid hydrogen was measured at LEAR. Branching ratios were obtained for Mathematical expression, and ηη(8.1±3.1)×10-5. An upper limit for Mathematical expression of 1.8×10-4 at 95% CL was found. The ratio of the branching ratios is BR(ηÏvariant)/BR(ηω)=0.51-0.06+0.20. For the ratio of branching ratios into two pseudoscalar mesons, we have BR(ηπ0)/BR(Ï€0Ï€0)=0.65±0.14, BR(ηη)/BR(Ï€0Ï€0), BR(ηη′)/BR(Ï€0Ï€0) at 95% CL, and BR(ηη)/BR(ηπ0). © 1989 Springer-Verlag.
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| 6. |
- Adiels, L, et al.
(author)
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Some results of experiment PS182 at LEAR
- 1986
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In: Antiproton 86. - Singspore : World Scientific Publishing. - 9971503131 ; , s. 199-204, s. 199-204
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Conference paper (other academic/artistic)
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| 7. |
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| 8. |
- Mardinoglu, Adil, 1982, et al.
(author)
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An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans
- 2018
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In: Cell Metabolism. - : Elsevier BV. - 1550-4131 .- 1932-7420. ; 27:3
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Journal article (peer-reviewed)abstract
- A carbohydrate-restricted diet is a widely recommended intervention for non-alcoholic fatty liver disease (NAFLD), but a systematic perspective on the multiple benefits of this diet is lacking. Here, we performed a short-term intervention with an isocaloric low-carbohydrate diet with increased protein content in obese subjects with NAFLD and characterized the resulting alterations in metabolism and the gut microbiota using a multi-omics approach. We observed rapid and dramatic reductions of liver fat and other cardiometabolic risk factors paralleled by (1) marked decreases in hepatic de novo lipogenesis; (2) large increases in serum beta-hydroxybutyrate concentrations, reflecting increased mitochondrial beta-oxidation; and (3) rapid increases in folate-producing Streptococcus and serum folate concentrations. Liver transcriptomic analysis on biopsy samples from a second cohort revealed downregulation of the fatty acid synthesis pathway and upregulation of folate-mediated one-carbon metabolism and fatty acid oxidation pathways. Our results highlight the potential of exploring diet-microbiota interactions for treating NAFLD.
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| 9. |
- Mardinoglu, Adil, 1982, et al.
(author)
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Personal model-assisted identification of NAD(+) and glutathione metabolism as intervention target in NAFLD
- 2017
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In: Molecular Systems Biology. - : EMBO. - 1744-4292. ; 13:3
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Journal article (peer-reviewed)abstract
- To elucidate the molecular mechanisms underlying non-alcoholic fatty liver disease (NAFLD), we recruited 86 subjects with varying degrees of hepatic steatosis (HS). We obtained experimental data on lipoprotein fluxes and used these individual measurements as personalized constraints of a hepatocyte genome-scale metabolic model to investigate metabolic differences in liver, taking into account its interactions with other tissues. Our systems level analysis predicted an altered demand for NAD(+) and glutathione (GSH) in subjects with high HS. Our analysis and metabolomic measurements showed that plasma levels of glycine, serine, and associated metabolites are negatively correlated with HS, suggesting that these GSH metabolism precursors might be limiting. Quantification of the hepatic expression levels of the associated enzymes further pointed to altered de novo GSH synthesis. To assess the effect of GSH and NAD(+) repletion on the development of NAFLD, we added precursors for GSH and NAD(+) biosynthesis to the Western diet and demonstrated that supplementation prevents HS in mice. In a proof-of-concept human study, we found improved liver function and decreased HS after supplementation with serine (a precursor to glycine) and hereby propose a strategy for NAFLD treatment.
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| 10. |
- Richter, B., et al.
(author)
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New results in the search for narrow states in the p system below threshold
- 1983
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 126:3-4, s. 284-288
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Journal article (peer-reviewed)abstract
- The γ-ray spectrum after p annihilation at rest was measured in two independent high-statistics runs. Both spectra show narrow peaks, corresponding to masses of 1210, 1638, 1694 and 1771 MeV.
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