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Search: WFRF:(Akdeniz B) > (2020-2022)

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  • Damato, V, et al. (author)
  • Rituximab abrogates aquaporin-4-specific germinal center activity in patients with neuromyelitis optica spectrum disorders
  • 2022
  • In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 119:24, s. e2121804119-
  • Journal article (peer-reviewed)abstract
    • By studying paired blood and deep cervical lymph node samples from patients with neuromyelitis optica spectrum disorders, our data provide evidence for a germinal center–based generation of aquaporin-4 antibodies. Frequent serum aquaporin-4 immunoglobulin Ms (IgMs) and shifts in IgG subclasses were observed alongside preferential synthesis of aquaporin-4 IgGs and aquaporin-4–reactive B cells within lymph nodes. Both intranodal synthesis of aquaporin-4 antibodies and intranodal aquaporin-4–reactive B cells were robustly eliminated with rituximab administration. This study systematically explores lymph nodes that drain the central nervous system (CNS) in patients with CNS autoimmunity and offers a potential explanation as to why rituximab is clinically highly efficacious in autoantibody-mediated diseases despite no accompanying reduction in serum autoantibody levels.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Berretta, A. (1)
Al-Diwani, A (1)
Sun, B (1)
Green, E (1)
Theorell, J (1)
Palace, J (1)
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Leite, MI (1)
Waters, P (1)
Woodhall, M (1)
Damato, V (1)
Kienzler, AK (1)
Makuch, M (1)
Handel, A (1)
Akdeniz, D (1)
Ramanathan, S (1)
Fower, A (1)
Whittam, D (1)
Gibbons, E (1)
McGlashan, N (1)
Huda, S (1)
Sheerin, F (1)
Jacob, A (1)
Irani, SR (1)
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University
Karolinska Institutet (1)
Language
English (1)
Year
2022 (1)

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