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Search: WFRF:(Bunikis Ignas) > (2004)

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  • Östberg, Yngve, et al. (author)
  • The etiological agent of Lyme disease, Borrelia burgdorferi, appears to contain
  • 2004
  • In: Journal of Bacteriology. - 0021-9193 .- 1098-5530. ; 186:24, s. 8472-8477
  • Journal article (peer-reviewed)abstract
    • Small regulatory RNAs (sRNAs) have recently been shown to be the main controllers of several regulatory pathways. The function of sRNAs depends in many cases on the RNA-binding protein Hfq, especially for sRNAs with an antisense function. In this study, the genome of Borrelia burgdorferi was subjected to different searches for sRNAs, including direct homology and comparative genomics searches and ortholog- and annotation-based search strategies. Two new sRNAs were found, one of which showed complementarity to the rpoS region, which it possibly controls by an antisense mechanism. The role of the other sRNA is unknown, although observed complementarities against particular mRNA sequences suggest an antisense mechanism. We suggest that the low level of sRNAs observed in B. burgdorferi is at least partly due to the presumed lack of both functional Hfq protein and RNase E activity.
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  • Result 1-1 of 1
Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Bergström, Sven (1)
Bunikis, Ignas (1)
Johansson, Jörgen (1)
Östberg, Yngve (1)
University
Umeå University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2004 (1)Undo refine

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