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Träfflista för sökning "WFRF:(Englund Karin) "

Search: WFRF:(Englund Karin)

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1.
  • Bergqvist, Filip, et al. (author)
  • Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells
  • 2019
  • In: Frontiers in Pharmacology. - : Frontiers Media SA. - 1663-9812. ; 10
  • Journal article (peer-reviewed)abstract
    • Pharmacological inhibition of microsomal prostaglandin E synthase (mPGES)-1 for selective reduction in prostaglandin E-2 (PGE(2)) biosynthesis is protective in experimental models of cancer and inflammation. Targeting mPGES-1 is envisioned as a safer alternative to traditional non-steroidal anti-inflammatory drugs (NSAIDs). Herein, we compared the effects of mPGES-1 inhibitor Compound III (CIII) with the cyclooxygenase (COX)-2 inhibitor NS-398 on protein and lipid profiles in interleukin (IL)-1 beta-induced A549 lung cancer cells using mass spectrometry. Inhibition of mPGES-1 decreased PGE(2) production and increased PGF(2 alpha) and thromboxane B-2 (TXB2) formation, while inhibition of COX-2 decreased the production of all three prostanoids. Our proteomics results revealed that CIII downregulated multiple canonical pathways including eIF2, eIF4/P70S6K, and mTOR signaling, compared to NS-398 that activated these pathways. Moreover, pathway analysis predicted that CIII increased cell death of cancer cells (Z = 3.8, p = 5.1E-41) while NS-398 decreased the same function (Z = -5.0, p = 6.5E-35). In our lipidomics analyses, we found alterations in nine phospholipids between the two inhibitors, with a stronger alteration in the lysophospholipid (LPC) profile with NS-398 compared to CIII. Inhibition of mPGES-1 increased the concentration of sphinganine and dihydroceramide (C16:0D hCer), while inhibition of COX-2 caused a general decrease in most ceramides, again suggesting different effects on cell death between the two inhibitors. We showed that CIII decreased proliferation and potentiated the cytotoxic effect of the cytostatic drugs cisplatin, etoposide, and vincristine when investigated in a live cell imaging system. Our results demonstrate differences in protein and lipid profiles after inhibition of mPGES-1 or COX-2 with important implications on the therapeutic potential of mPGES-1 inhibitors as adjuvant treatment in cancer. We encourage further investigations to illuminate the clinical benefit of mPGES-1 inhibitors in cancer.
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  • Englund, Anna-Lena, 1949-, et al. (author)
  • Värdegrunden reducerad till metod
  • 2009
  • In: Pedagogiska magasinet. - Stockholm : Lärarförbundet. - 1401-3320. ; 13:4, s. 18-21
  • Journal article (pop. science, debate, etc.)abstract
    • Det behövs en etisk vändning i diskussionen om främjande och förebyggande program. Alltför stort intresse riktas mot frågan om evidens och effektivitet och alltför lite intresse riktas mot värdefrågorna. Vad innebäör det för lärarens professionalism om manualstyrda aktiviteter ersätter samtal och samspel?
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  • RECLAIMING FUTURES : Ungdomar sätter agendan på vetenskapsfestival
  • 2022
  • Artistic work (peer-reviewed)abstract
    • I Reclaiming Futures - Storying Change möts ungdomar och forskare för samtal om klimatförändringar, miljöfrågor och vårt förhållande till naturen. Projektet har bland annat resulterat i ett antal kortfilmer. Nu presenteras delar av arbetet på en vetenskapsfestival med ett gediget program skapat och producerat av ungdomarna i samarbete med forskare och kulturaktörer. 
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  • Beime, Kristina S., 1984-, et al. (author)
  • Theorizing the subjectivizing powers of market-based technologies : Looking beyond coercion and seduction
  • 2024
  • In: Critical Perspectives on Accounting. - : Elsevier. - 1045-2354 .- 1095-9955. ; 99
  • Journal article (peer-reviewed)abstract
    • Existing theorizations on how the proliferation of market-based technologies within universities come to foster so-called academic performer subjectivities have mainly drawn attention to their coercive and seductive powers. However, while these theorizations help explain why researchers either unwillingly adapt to, or identify with and cherish, their neoliberal ideals, they are less useful to explain recent empirical results showing that many researchers willingly comply yet are very critical of the very same ideals. Drawing upon an interview study of Swedish researchers, we address this theoretical gap in the literature by analytically disentangling three important qualities of the technologies per se, in terms of them producing performance numbers characterized by Specificness, Ongoingness, and Emptiness (SOE). These three qualities do not only have the dual power to interchangeably provoke bitter and sweet feelings, but also to foster the adoption of an academic performer subjectivity. In fact, it is precisely by provoking bittersweet feelings that these qualities break the sharp edges of pure coercion and seduction, thereby fostering a type of low-affective, yet highly persuasive form of reasoning about pros and cons of market-based technologies, which make their neoliberal ideals seem acceptable and reasonable at the end of the day.
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  • Result 1-10 of 90
Type of publication
journal article (59)
conference paper (9)
reports (6)
doctoral thesis (6)
other publication (5)
research review (2)
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book chapter (2)
artistic work (1)
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Type of content
peer-reviewed (69)
other academic/artistic (20)
pop. science, debate, etc. (1)
Author/Editor
Englund, Martin (14)
Turkiewicz, Aleksand ... (12)
Englund Johansson, U ... (10)
Warfvinge, Karin (10)
Englund, Elisabet (9)
Lundberg, Cecilia (7)
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Kiadaliri, Ali (5)
Nilsson, Karin (5)
Eloranta, Sandra (4)
Hjalgrim, Henrik (4)
Seger, Karin, 1975- (4)
Noaksson, Karin (4)
Englund, Göran, 1957 ... (4)
Abbot, Stewart (3)
Englund, Hans, 1971- (3)
Olsson, Björn (3)
Wikström, Anna-Karin (3)
Elden, Helen, 1959 (3)
Gustafson, Lars (3)
Sartipy, Peter (3)
Frobell, Richard (2)
Johansson, Petter (2)
Smedby, Karin E. (2)
Glimelius, Ingrid, 1 ... (2)
Lindahl, Anders, 195 ... (2)
Nilsson, Christer (2)
Nyström, Maria (2)
Elfvin, Anders, 1971 (2)
Sengpiel, Verena, 19 ... (2)
Shaat, Nael (2)
van Westen, Danielle (2)
Ahrens, Lutz (2)
Wiberg, Karin (2)
Englund, Sophie (2)
Östlund, Anna (2)
Lindegren, Klara (2)
Berntorp, Kerstin (2)
Hughes, Velocity (2)
Knop, Filip K (2)
Ljungman, Gustaf, 19 ... (2)
Ljungman, Gustaf (2)
André, Karin (2)
Appelberg, Jonas (2)
Englund, Tomas, 1946 ... (2)
Bergh, Andreas, 1964 ... (2)
Englund, Tomas, Prof ... (2)
Mobley, Kenyon B. (2)
Kristensen, Lars (2)
Jong, Miek C, 1968- (2)
Jong, Mats, 1968- (2)
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University
Lund University (41)
Uppsala University (13)
Örebro University (12)
University of Gothenburg (11)
Linnaeus University (7)
Mid Sweden University (6)
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University of Borås (6)
Karolinska Institutet (6)
Umeå University (5)
Swedish University of Agricultural Sciences (4)
Mälardalen University (3)
Linköping University (3)
Jönköping University (3)
University of Skövde (3)
Royal Institute of Technology (2)
Stockholm University (2)
Södertörn University (2)
Chalmers University of Technology (2)
Kristianstad University College (1)
Luleå University of Technology (1)
The Swedish School of Sport and Health Sciences (1)
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Language
English (80)
Swedish (10)
Research subject (UKÄ/SCB)
Medical and Health Sciences (60)
Social Sciences (16)
Natural sciences (12)
Engineering and Technology (3)
Humanities (3)
Agricultural Sciences (1)

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