↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "WFRF:(Hoenicke L.) "

Search: WFRF:(Hoenicke L.)

Result 1-3 of 3

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Schneider, K. M., et al. (author) Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment 2022 In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1 Journal article (peer-reviewed)abstract Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, and therapeutic options for advanced HCC are limited. Here, we observe that intestinal dysbiosis affects antitumor immune surveillance and drives liver disease progression towards cancer. Dysbiotic microbiota, as seen in Nlrp6(-/-) mice, induces a Toll-like receptor 4 dependent expansion of hepatic monocytic myeloid-derived suppressor cells (mMDSC) and suppression of T-cell abundance. This phenotype is transmissible via fecal microbiota transfer and reversible upon antibiotic treatment, pointing to the high plasticity of the tumor microenvironment. While loss of Akkermansia muciniphila correlates with mMDSC abundance, its reintroduction restores intestinal barrier function and strongly reduces liver inflammation and fibrosis. Cirrhosis patients display increased bacterial abundance in hepatic tissue, which induces pronounced transcriptional changes, including activation of fibro-inflammatory pathways as well as circuits mediating cancer immunosuppression. This study demonstrates that gut microbiota closely shapes the hepatic inflammatory microenvironment opening approaches for cancer prevention and therapy. Steatohepatitis is a chronic hepatic inflammation associated with increased risk of hepatocellular carcinoma progression. Here the authors show that intestinal dysbiosis in mice lacking the inflammasome sensor molecule NLRP6 aggravates steatohepatitis and accelerates liver cancer progression, a process that can be delayed by antibiotic treatment.
2.	Wilharm, A, et al. (author) Correction: Microbiota-dependent expansion of testicular IL-17-producing Vγ6+ γδ T cells upon puberty promotes local tissue immune surveillance 2021 In: Mucosal immunology. - : Elsevier BV. - 1935-3456 .- 1933-0219. ; 14:1, s. 278-278 Journal article (other academic/artistic)
3.	Wilharm, A, et al. (author) Microbiota-dependent expansion of testicular IL-17-producing Vγ6+ γδ T cells upon puberty promotes local tissue immune surveillance 2021 In: Mucosal immunology. - : Elsevier BV. - 1935-3456 .- 1933-0219. ; 14:1, s. 242-252 Journal article (peer-reviewed)

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-3 of 3

Refine your search

Type of publication: journal article (3)

Type of content: peer-reviewed (2); other academic/artistic (1)

Author/Editor: Strowig, T. (3); Hoenicke, L. (3); Ribeiro, M (2); Carvalho, T (2); Prinz, I. (2); Sandrock, I. (2); show more...; Wilharm, A. (2); Reinhardt, A (2); Brigas, HC (2); Amado, T (2); Demera, A (2); Ribot, JC (2); Marschall, Hanns-Ulr ... (1); Latz, E (1); Holland, C. H. (1); Trautwein, C (1); Schneider, K. M. (1); Trebicka, J. (1); Saez-Rodriguez, J (1); De Vos, W (1); Strnad, P (1); Lelouvier, B (1); Gui, W. F. (1); Schneider, C. V. (1); Muthukumarasamy, U. (1); Mohs, A. (1); Candels, L. S. (1); Elfers, C. (1); Kilic, K. (1); Galvez, E. J. C. (1); Schierwagen, R. (1); Wirtz, T. H. (1); show less...

University: Karolinska Institutet (2); University of Gothenburg (1)

Language: English (3)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view