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- Ahlin, Sofie, 1985, et al.
(author)
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Macrophage Gene Expression in Adipose Tissue is Associated with Insulin Sensitivity and Serum Lipid Levels Independent of Obesity.
- 2013
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In: Obesity (Silver Spring, Md.). - : Wiley. - 1930-739X .- 1930-7381. ; 21:12
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Journal article (peer-reviewed)abstract
- Objective: Obesity is linked to both increased metabolic disturbances and increased adipose tissue macrophage infiltration. However, whether macrophage infiltration directly influences human metabolism is unclear. The aim of this study was to investigate if there are obesity-independent links between adipose tissue macrophages and metabolic disturbances. Design and Methods: Expression of macrophage markers in adipose tissue was analyzed by DNA microarrays in the SOS Sib Pair study and in patients with type 2 diabetes and a BMI-matched healthy control group. Results: The expression of macrophage markers in adipose tissue was increased in obesity and associated with several metabolic and anthropometric measurements. After adjustment for BMI, the expression remained associated with insulin sensitivity, serum levels of insulin, C-peptide, high density lipoprotein cholesterol (HDL-cholesterol) and triglycerides. In addition, the expression of most macrophage markers was significantly increased in patients with type 2 diabetes compared to the control group. Conclusion: Our study shows that infiltration of macrophages in human adipose tissue, estimated by the expression of macrophage markers, is increased in subjects with obesity and diabetes and associated with insulin sensitivity and serum lipid levels independent of BMI. This indicates that adipose tissue macrophages may contribute to the development of insulin resistance and dyslipidemia.
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- Aramrattana, Maytheewat, 1988-, et al.
(author)
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A Novel Risk Indicator for Cut-In Situations
- 2020
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In: 2020 IEEE 23rd International Conference on Intelligent Transportation Systems, ITSC 2020. - Piscataway, NJ : Institute of Electrical and Electronics Engineers Inc.. - 9781728141497 - 9781728141503
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Conference paper (peer-reviewed)abstract
- Cut-in situations occurs when a vehicle intentionally changes lane and ends up in front of another vehicle or in-between two vehicles. In such situations, having a method to indicate the collision risk prior to making the cut-in maneuver could potentially reduce the number of sideswipe and rear end collisions caused by the cut-in maneuvers. This paper propose a new risk indicator, namely cut-in risk indicator (CRI), as a way to indicate and potentially foresee collision risks in cut-in situations. As an example use case, we applied CRI on data from a driving simulation experiment involving a manually driven vehicle and an automated platoon in a highway merging situation. We then compared the results with time-to-collision (TTC), and suggest that CRI could correctly indicate collision risks in a more effective way. CRI can be computed on all vehicles involved in the cut-in situations, not only for the vehicle that is cutting in. Making it possible for other vehicles to estimate the collision risk, for example if a cut-in from another vehicle occurs, the surrounding vehicles could be warned and have the possibility to react in order to potentially avoid or mitigate accidents.
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| 8. |
- Aramrattana, Maytheewat, et al.
(author)
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A simulation framework for cooperative intelligent transport systems testing and evaluation
- 2017
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In: Transportation Research Part F. - Kidlington : Pergamon Press. - 1369-8478 .- 1873-5517.
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Journal article (peer-reviewed)abstract
- Connected and automated driving in the context of cooperative intelligent transport systems (C-ITS) is an emerging area in transport systems research. Interaction and cooperation between actors in transport systems are now enabled by the connectivity by means of vehicle-to-vehicle and vehicle-to-infrastructure (V2X) communication. To ensure the goals of C-ITS, which are safer and more efficient transport systems, testing and evaluation are required before deployment of C-ITS applications. Therefore, this paper presents a simulation framework—consisting of driving-, traffic-, and network-simulators—for testing and evaluation of C-ITS applications. Examples of cooperative adaptive cruise control (CACC) applications are presented, and are used as test cases for the simulation framework as well as to elaborate on potential use cases of it. Challenges from combining the simulators into one framework, and limitations are reported and discussed. Finally, the paper concludes with future development directions, and applications of the simulation framework in testing and evaluation of C-ITS. © 2017 Elsevier Ltd. All rights reserved.
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| 9. |
- Aramrattana, Maytheewat, et al.
(author)
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A Simulation Study on Effects of Platooning Gaps on Drivers of Conventional Vehicles in Highway Merging Situations
- 2021
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In: IEEE transactions on intelligent transportation systems (Print). - Piscataway, NJ : Institute of Electrical and Electronics Engineers Inc.. - 1524-9050 .- 1558-0016.
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Journal article (peer-reviewed)abstract
- Platooning refers to a group of vehicles that--enabled by wireless vehicle-to-vehicle (V2V) communication and vehicle automation--drives with short inter-vehicular distances. Before its deployment on public roads, several challenging traffic situations need to be handled. Among the challenges are cut-in situations, where a conventional vehicle--a vehicle that has no automation or V2V communication--changes lane and ends up between vehicles in a platoon. This paper presents results from a simulation study of a scenario, where a conventional vehicle, approaching from an on-ramp, merges into a platoon of five cars on a highway. We created the scenario with four platooning gaps: 15, 22.5, 30, and 42.5 meters. During the study, the conventional vehicle was driven by 37 test persons, who experienced all the platooning gaps using a driving simulator. The participants' opinions towards safety, comfort, and ease of driving between the platoon in each gap setting were also collected through a questionnaire. The results suggest that a 15-meter gap prevents most participants from cutting in, while causing potentially dangerous maneuvers and collisions when cut-in occurs. A platooning gap of at least 30 meters yield positive opinions from the participants, and facilitating more smooth cut-in maneuvers while less collisions were observed.
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| 10. |
- Aramrattana, Maytheewat, et al.
(author)
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Cooperative Driving Simulation
- 2016
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In: Proceedings of the Driving Simulation Conference 2016. ; , s. 123-132
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Conference paper (peer-reviewed)abstract
- For a few decades, driving simulators have been supporting research and development of advanced driver assistance systems (ADAS). In the near future, connected vehicles are expected to be deployed. Driving simulators will need to support evaluation of cooperative driving applications within cooperative intelligent transportation systems (C-ITS) scenarios. C-ITS utilize vehicle-to-vehicle and vehicle-to-infrastructure (V2X) communication. Simulation of the inter vehicle communication is often not supported in driving simulators. On the other hand, previous efforts have been made to connect network simulators and traffic simulators, to perform C-ITS simulations. Nevertheless, interactions between actors in the system is an essential aspect of C-ITS. Driving simulators can provide the opportunity to study interactions and reactions of human drivers to the system. This paper present simulation of a C-ITS scenario using a combination of driving, network, and traffic simulators. The architecture of the solution and important challenges of the integration are presented. A scenario from Grand Cooperative Driving Challenge (GCDC) 2016 is implemented in the simulator as an example use case. Lastly, potential usages and future developments are discussed.
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