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- Korenblik, R., et al.
(author)
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Dragon 1 Protocol Manuscript : Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE/HVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy
- 2022
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In: Cardiovascular and Interventional Radiology. - : Springer. - 0174-1551 .- 1432-086X. ; 45, s. 1391-1398
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Journal article (peer-reviewed)abstract
- Study Purpose The DRAGON 1 trial aims to assess training, implementation, safety and feasibility of combined portal- and hepatic-vein embolization (PVE/HVE) to accelerate future liver remnant (FLR) hypertrophy in patients with borderline resectable colorectal cancer liver metastases. Methods The DRAGON 1 trial is a worldwide multicenter prospective single arm trial. The primary endpoint is a composite of the safety of PVE/HVE, 90-day mortality, and one year accrual monitoring of each participating center. Secondary endpoints include: feasibility of resection, the used PVE and HVE techniques, FLR-hypertrophy, liver function (subset of centers), overall survival, and disease-free survival. All complications after the PVE/HVE procedure are documented. Liver volumes will be measured at week 1 and if applicable at week 3 and 6 after PVE/HVE and follow-up visits will be held at 1, 3, 6, and 12 months after the resection. Results Not applicable. Conclusion DRAGON 1 is a prospective trial to assess the safety and feasibility of PVE/HVE. Participating study centers will be trained, and procedures standardized using Work Instructions (WI) to prepare for the DRAGON 2 randomized controlled trial. Outcomes should reveal the accrual potential of centers, safety profile of combined PVE/HVE and the effect of FLR-hypertrophy induction by PVE/HVE in patients with CRLM and a small FLR.
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| 4. |
- Martel, I., et al.
(author)
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An innovative Superconducting Recoil Separator for HIE-ISOLDE
- 2023
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In: Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms. - : ELSEVIER. - 0168-583X .- 1872-9584. ; 541, s. 176-179
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Journal article (peer-reviewed)abstract
- The ISOLDE Scientific Infrastructure at CERN offers a unique range of post-accelerated radioactive beams. The scientific program can be improved with the “Isolde Superconducting Recoil Separator” (ISRS), an innovative spectrometer able to deliver unprecedented (A, Z) resolution. In this paper we present an overview of the physics and ongoing technical developments.
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- Távora, V.G., et al.
(author)
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Strong coupling effects on near-barrier 15C + 208Pb elastic scattering
- 2024
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In: Physics Letters B. - 0370-2693. ; 855
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Journal article (peer-reviewed)abstract
- The presence of a neutron halo in 15C has been demonstrated in several reaction experiments at intermediate energies. In the present study, the dynamical effects of this structure are observed for the first time at Coulomb barrier energies in the 15C + 208Pb quasi-elastic scattering at MeV, measured at the HIE-ISOLDE facility, CERN using the high-granularity detector array GLORIA. A combined continuum discretised coupled channels and coupled reaction channels calculation describes the data well and significant coupling effects due both to breakup and single-neutron stripping are identified.
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| 6. |
- Mahout, G., et al.
(author)
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Irradiation studies of multimode optical fibres for use in ATLAS front-end links
- 2000
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In: Nuclear Instruments and Methods in Physics Research Section A. - 0168-9002 .- 1872-9576. ; 446:3, s. 426-434
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Journal article (peer-reviewed)abstract
- The radiation tolerance of three multimode optical fibres has been investigated to establish their suitability for the use in the front-end data links of the ATLAS experiment. Both gamma and neutron irradiation studies are reported. A step-index fibre with a pure silica core showed an induced attenuation of similar to 0.05 dB/m at 330 kGy(Si) and 1 x 10(15) n(1 MeV Si)/cm(2) and is suitable for use with the inner detector links which operate at 40-80 Mb/s. A graded-index fibre with a predominantly germanium-doped core exhibits an induced attenuation of similar to 0.1 dB/m at 800 Gy(Si) and 2 x 10(13) n(1 MeV Si)/cm(2) and is suitable for the calorimeter links which operate at 1.6 Gb/s. Measurements of the dose rate dependence of the induced attenuation indicate that the attenuation in ATLAS will be lower.
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| 7. |
- Ovejas, J. D., et al.
(author)
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Halo effects in the low-energy scattering of 15 C with heavy targets
- 2020
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In: Acta Physica Polonica, Series B.. - 1509-5770 .- 0587-4254. ; 51:3, s. 731-736
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Journal article (peer-reviewed)abstract
- The neutron-rich carbon isotope 15C was postulated to be a halo nucleus (Sn = 1215 keV, S2n = 9395 keV) according to different high-energy experiments. If so, it would be the only halo nucleus exhibiting a "pure" s-wave structure of the ground state. At low collision energies, the effect of this halo structure should manifest as a strong absorption pattern in the angular distribution of the elastic cross section, with a total suppression of the nuclear rainbow due to the large neutron transfer and breakup probabilities, enhanced by the halo configuration. The IS619 experiment, carried out at the HIE-ISOLDE facility at CERN (Switzerland), is the first dynamical study of this nucleus at energies around the Coulomb barrier. It aims to probe the halo structure via the measurement of the elastic cross section on a high-Z 208Pb target. Preliminary results of the elastic cross section are discussed and compared to Optical Model calculations.
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| 8. |
- Ovejas, J. D., et al.
(author)
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Study of the scattering of 15C at energies around the Coulomb barrier
- 2020
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In: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 1643:1
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Conference paper (peer-reviewed)abstract
- The neutron rich carbon isotope 15C is the only known case of an almost "pure"2s1/2 single-neutron halo ground state configuration. At collision energies around the Coulomb barrier the reaction dynamics is expected to be dominated by single neutron transfer and breakup. To investigate these effects, we have measured the scattering of 15C with a 208Pb target at 65 MeV at the HIE-ISOLDE facility in CERN (Geneva, Switzerland). The preliminary data demonstrates the presence of a strong long-range absorption pattern in the angular distribution of the elastic cross section. The results are discussed in the framework of Optical Model calculations.
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| 9. |
- Spartà, R., et al.
(author)
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8B reaction dynamics researched at HIE-ISOLDE
- 2024
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In: Nuovo Cimento della Societa Italiana di Fisica C. - 2037-4909 .- 1826-9885. ; 47:2
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Journal article (peer-reviewed)abstract
- For the first time a measurement of 8B + 64Zn reaction has been performed at HIE-ISOLDE at CERN at energies around the Coulomb barrier, to understand how the debated halo structure of the light nucleus can affect reaction dynamics.
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| 10. |
- Cubero, M., et al.
(author)
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Do Halo Nuclei Follow Rutherford Elastic Scattering at Energies Below the Barrier? The Case of 11Li
- 2012
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In: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 109:26
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Journal article (peer-reviewed)abstract
- The first measurement of the elastic scattering of the halo nucleus 11Li and its core 9Li on 208Pb at energies near the Coulomb barrier is presented. The 11Li+208Pb elastic scattering shows a strong reduction with respect to the Rutherford cross section, even at energies well below the barrier and down to very small scattering angles. This drastic change of the elastic differential cross section observed in 11Li+208Pb is the consequence of the halo structure of 11Li, as it is not observed in the elastic scattering of its core 9Li at the same energies. Four-body continuum-discretized coupled-channels calculations, based on a three-body model of the 11Li projectile, are found to explain the measured angular distributions and confirm that the observed reduction is mainly due to the strong Coulomb coupling to the dipole states in the low-lying continuum of 11Li. These calculations suggest the presence of a low-lying dipole resonance in 11Li close to the breakup threshold.
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