SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Mazari Aslam M. A.) srt2:(2019)"

Search: WFRF:(Mazari Aslam M. A.) > (2019)

  • Result 1-1 of 1
Sort/group result
   
EnumerationReferenceCoverFind
1.
  • Lindström, Helena, et al. (author)
  • Potent inhibitors of equine steroid isomerase EcaGST A3-3
  • 2019
  • In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 14:3
  • Journal article (peer-reviewed)abstract
    • Equine glutathione transferase A3-3 (EcaGST A3-3) belongs to the superfamily of detoxication enzymes found in all higher organisms. However, it is also the most efficient steroid double-bond isomerase known in mammals. Equus ferus caballus shares the steroidogenic pathway with Homo sapiens, which makes the horse a suitable animal model for investigations of human steroidogenesis. Inhibition of the enzyme has potential for treatment of steroid-hormone-dependent disorders. Screening of a library of FDA-approved drugs identified 16 out of 1040 compounds, which at 10 mu M concentration afforded at least 50% inhibition of EcaGST A3-3. The most potent inhibitors, anthralin, sennoside A, tannic acid, and ethacrynic acid, were characterized by IC50 values in the submicromolar range when assayed with the natural substrate Delta(5)-androstene-3,17-dione.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-1 of 1
Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Mannervik, Bengt (1)
Musdal, Yaman (1)
Mazari, Aslam M. A. (1)
Lindström, Helena (1)
University
Stockholm University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Natural sciences (1)
Year
2019 (1)Undo refine

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view