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Search: WFRF:(Polleryd P)

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  • Hansson, H A, et al. (author)
  • Evidence indicating trophic importance of IGF-I in regenerating peripheral nerves
  • 1986
  • In: Acta Physiologica Scandinavica. - : Wiley. - 0001-6772 .- 1365-201X. ; 126:4, s. 14-609
  • Journal article (peer-reviewed)abstract
    • The mechanisms influencing regeneration of peripheral nerves are incompletely known, but growth factors are supposed to play a key role. In the present study, we demonstrate, with the aid of immunohistochemical methods, that somatomedin C (Sm-C/insulin-like growth factor I/IGF-I) rapidly increased from low to high concentrations, reaching peak values in 2 weeks, in regenerating sciatic nerves of adult rats. In addition, IGF-I was demonstrated extracellularly, never observed in the control nerves. Reactive Schwann cells appeared to be the major source for IGF-synthesis. Higher concentrations were seen in tubulated nerves as compared to sutured ones. It is proposed that IGF-I exerts important growth supporting effects on regenerating peripheral nerves.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Dahlin, L. B. (1)
Fryklund, L (1)
Danielsen, Nils (1)
Hansson, H. A. (1)
Stemme, S (1)
Lundborg, G (1)
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Skottner, Anna (1)
Nachemson, A K (1)
Polleryd, P (1)
Rozell, Bjorn (1)
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University
Lund University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
1986 (1)

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