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Träfflista för sökning "WFRF:(Sáez Comet Luis) srt2:(2011)"

Search: WFRF:(Sáez Comet Luis) > (2011)

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  • Bossini-Castillo, Lara, et al. (author)
  • Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population.
  • 2011
  • In: Rheumatology (Oxford, England). - : Oxford University Press (OUP). - 1462-0332 .- 1462-0324. ; 50, s. 1976-1981
  • Journal article (peer-reviewed)abstract
    • Objectives. The aim of this study was to confirm the implication of macrophage migration inhibitory factor (MIF) gene in SSc susceptibility or clinical phenotypes in a large European population.Methods. A total of 3800 SSc patients and 4282 healthy controls of white Caucasian ancestry from eight different European countries were included in the study. The MIF -173 single nucleotide polymorphism (SNP) was selected as genetic marker and genotyped using Taqman 5' allelic discrimination assay.Results. The MIF -173 SNP showed association with SSc [P = 0.04, odds ratio (OR) = 1.10, 95% CI 1.00, 1.19]. Analysis of the MIF -173 polymorphism according to SSc clinical phenotype revealed that the frequency of the -173*C allele was significantly higher in the dcSSc group compared with controls (P = 5.30E-03, OR = 1.21, 95% CI 1.07, 1.38). Conversely, the frequency of the MIF -173*C allele was significantly underrepresented in the lcSSc group compared with dcSSc patients, supporting previous findings [(P = 0.04, OR = 0.86, 95% CI 0.75, 0.99); meta-analysis including previous results (P = 0.005, OR = 0.83, 95% CI 0.73, 0.94)].Conclusion. Our results confirm the role of MIF -173 promoter polymorphism in SSc, and provide evidence of a strong association with the dcSSc subgroup of patients. Hence, the MIF -173 variant is confirmed as a promising clinical phenotype genetic marker.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
other academic/artistic (1)
peer-reviewed (1)
Author/Editor
Witte, Torsten (2)
Martin, Javier (2)
Nordin, Annika (2)
Hesselstrand, Roger (2)
Herrick, Ariane (2)
Worthington, Jane (2)
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Denton, Christopher (2)
Fonseca, Carmen (2)
Riemekasten, Gabriel ... (2)
Vonk, Madelon C (2)
Beretta, Lorenzo (2)
Airó, Paolo (2)
Radstake, Timothy R ... (2)
Simeon, Carmen P. (2)
Carreira, Patricia (2)
Hunzelmann, Nicolas (2)
Kreuter, Alexander (2)
Voskuyl, Alexandre E ... (2)
Schuerwegh, Annemie ... (2)
Lunardi, Claudio (2)
Scorza, Raffaella (2)
Shiels, Paul (2)
van Laar, Jacob M. (2)
Espinosa, Gerard (2)
Garcia-Hernandez, Fr ... (2)
Rodríguez-Rodríguez, ... (2)
Rodríguez-Carballeir ... (2)
Sáez-Comet, Luis (2)
Hoffmann-Vold, Anna- ... (2)
Rueda, Blanca (1)
Koeleman, Bobby P C (1)
De Langhe, Ellen (1)
Bossini-Castillo, La ... (1)
Castellvi, Ivan (1)
Koeleman, Bobby P. (1)
Palm, Oyvind (1)
Navarrete, Nuria (1)
Vicente-Rabaneda, Es ... (1)
Tolosa, Carlos (1)
Victoria Egurbide, M ... (1)
Fonollosa, Vicente (1)
Gonzalez-Gay, Miguel ... (1)
Smith, Vanessa (1)
Madhok, Rajan (1)
Callejas-Rubio, José ... (1)
Camps, María T (1)
López-Longo, Francis ... (1)
Hernández-Hernández, ... (1)
Egurbide, María Vict ... (1)
Vanthuyne, Marie (1)
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University
Lund University (2)
Karolinska Institutet (2)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)
Year
2011 (2)Undo refine

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