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- Tamura, K, et al.
(author)
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Fibronectin stimulates transcription of the platelet-derived growth factor beta-receptor in cultured rat aortic smooth muscle cells.
- 1998
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In: Biochemical and biophysical research communications. - : Elsevier BV. - 0006-291X. ; 251:3, s. 677-80
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Journal article (peer-reviewed)abstract
- Fibronectin seems to play an important role in promoting the characteristic changes of vascular smooth muscle cells in diabetes mellitus including overexpression of the platelet-derived growth factor beta-receptor. To determine the regulatory mechanism of the beta-receptor by fibronectin, we have analyzed the effect of fibronectin on the expression of the beta-receptor in cultured rat aortic smooth muscle cells using the beta-receptor promoter/luciferase expression vector system. Fibronectin was found to stimulate the expression of the beta-receptor at the transcriptional level. Both a MEK1 inhibitor PD98059 and a tyrosine kinase inhibitor herbimycin A significantly inhibited the fibronectin-stimulated receptor transcription. Herbimycin A also completely inhibited the fibronectin-stimulated increase in tyrosine phosphorylation of focal adhesion kinase. These data suggest the involvement of the integrin-mediated mitogen-activated protein kinase pathway downstream of fibronectin stimulation in the activation process of the beta-receptor promoter.
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- Noakes, DR, et al.
(author)
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Spin dynamics and freezing in magnetic rare-earth quasicrystals
- 1998
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In: PHYSICS LETTERS A. - : ELSEVIER SCIENCE BV. - 0375-9601. ; 238:2-3, s. 197-202
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Journal article (other academic/artistic)abstract
- Muon spin relaxation measurements of RE8Mg42Zn50 (RE = Gd, Tb) quasicrystals have revealed slower spin dynamics and more prompt spin freezing for Tb than Gd, due to "crystalline electric field" splitting in low rare-earth site symmetry. Inhomogeneous spin
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