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1.	Dina, Christian, et al. (author) Variation in FTO contributes to childhood obesity and severe adult obesity. 2007 In: Nature genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 39:6, s. 724-6 Journal article (peer-reviewed)abstract We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 x 10(-26) in 2,900 affected individuals and 5,100 controls. The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.

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Author/Editor: Carlsson, Lena M S, ... (1); Jacobson, Peter, 196 ... (1); Pattou, Francois (1); Hercberg, Serge (1); Froguel, Philippe (1); Meyre, David (1); show more...; Kovacs, Peter (1); Balkau, Beverley (1); Lecoeur, Cecile (1); Ruiz, Juan (1); Dina, Christian (1); Durand, Emmanuelle (1); Marre, Michel (1); Potoczna, Natascha (1); Horber, Fritz (1); Le Stunff, Catherine (1); Kiess, Wieland (1); Körner, Antje (1); Cauchi, Stephane (1); Gallina, Sophie (1); Vatin, Vincent (1); Delplanque, Jérome (1); Vaillant, Emmanuel (1); Weill, Jacques (1); Levy-Marchal, Claire (1); Bougnères, Pierre (1); Chèvre, Jean-Claude (1); show less...

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