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Search: WFRF:(Zhao Zhen Zhen) > Örebro University

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  • Wu, Jie, et al. (author)
  • The impact of kidney function on plasma neurofilament light and phospho-tau 181 in a community-based cohort : the Shanghai Aging Study
  • 2024
  • In: Alzheimer's Research & Therapy. - : BioMed Central (BMC). - 1758-9193. ; 16:1
  • Journal article (peer-reviewed)abstract
    • BACKGROUND: The blood-based biomarkers are approaching the clinical practice of Alzheimer's disease (AD). Chronic kidney disease (CKD) has a potential confounding effect on peripheral protein levels. It is essential to characterize the impact of renal function on AD markers.METHODS: Plasma phospho-tau181 (P-tau181), and neurofilament light (NfL) were assayed via the Simoa HD-X platform in 1189 dementia-free participants from the Shanghai Aging Study (SAS). The estimated glomerular filter rate (eGFR) was calculated. The association between renal function and blood NfL, P-tau181 was analyzed. An analysis of interactions between various demographic and comorbid factors and eGFR was conducted.RESULTS: The eGFR levels were negatively associated with plasma concentrations of NfL and P-tau181 (B = - 0.19, 95% CI - 0.224 to - 0.156, P < 0.001; B = - 0.009, 95% CI - 0.013 to -0.005, P < 0.001, respectively). After adjusting for demographic characteristics and comorbid diseases, eGFR remained significantly correlated with plasma NfL (B = - 0.010, 95% CI - 0.133 to - 0.068, P < 0.001), but not with P-tau181 (B = - 0.003, 95% CI - 0.007 to 0.001, P = 0.194). A significant interaction between age and eGFR was found for plasma NfL (Pinteraction < 0.001). In participants ≥ 70 years and with eGFR < 60 ml/min/1.73 m2, the correlation between eGFR and plasma NfL was significantly remarkable (B = - 0.790, 95% CI - 1.026 to - 0,554, P < 0.001).CONCLUSIONS: Considering renal function and age is crucial when interpreting AD biomarkers in the general aging population.
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journal article (1)
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peer-reviewed (1)
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Ding, Ding (1)
Cao, Yang, Associate ... (1)
Chen, Jing (1)
Wu, Jie (1)
Zheng, Li (1)
Xiao, Zhenxu (1)
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Wu, Wanqing (1)
Zhao, Qianhua (1)
Liang, Xiaoniu (1)
Wang, Mengjing (1)
Ma, Xiaoxi (1)
Ding, Saineng (1)
Luo, Jianfeng (1)
Hong, Zhen (1)
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Medical and Health Sciences (1)
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