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Träfflista för sökning "hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Klinisk medicin) hsv:(Geriatrik) ;lar1:(slu);pers:(Paul Arun)"

Search: hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Klinisk medicin) hsv:(Geriatrik) > Swedish University of Agricultural Sciences > Paul Arun

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  • Boutajangout, Allal, et al. (author)
  • Affibody-Mediated Sequestration of Amyloid beta Demonstrates Preventive Efficacy in a Transgenic Alzheimer's Disease Mouse Model
  • 2019
  • In: Frontiers in Aging Neuroscience. - : Frontiers Media S.A.. - 1663-4365 .- 1663-4365. ; 11
  • Journal article (peer-reviewed)abstract
    • Different strategies for treatment and prevention of Alzheimer's disease (AD) are currently under investigation, including passive immunization with anti-amyloid beta (anti-A beta) monoclonal antibodies (mAbs). Here, we investigate the therapeutic potential of a novel type of A beta-targeting agent based on an affibody molecule with fundamentally different properties to mAbs. We generated a therapeutic candidate, denoted Z(SYM73)-albumin-binding domain (ABD; 16.8 kDa), by genetic linkage of the dimeric Z(SYM73) affibody for sequestering of monomeric A beta-peptides and an ABD for extension of its in vivo half-life. Amyloid precursor protein (APP)/PS1 transgenic AD mice were administered with Z(SYM73)-ABD, followed by behavioral examination and immunohistochemistry. Results demonstrated rescued cognitive functions and significantly lower amyloid burden in the treated animals compared to controls. No toxicological symptoms or immunology-related side-effects were observed. To our knowledge, this is the first reported in vivo investigation of a systemically delivered scaffold protein against monomeric A beta, demonstrating a therapeutic potential for prevention of AD.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Ståhl, Stefan (1)
Frejd, Fredrik Y. (1)
Löfblom, John (1)
Boutajangout, Allal (1)
Lindberg, Hanna (1)
Awwad, Abdulaziz (1)
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Härd, Torleif (1)
Wisniewski, Thomas (1)
Baitalmal, Rabaa (1)
Almokyad, Ismail (1)
Hoiden-Guthenberg, I ... (1)
Gunneriusson, Elin (1)
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University
Royal Institute of Technology (1)
Swedish University of Agricultural Sciences  (1)Undo refine
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2019 (1)

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