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  • Joshi, Rubin Narayan, et al. (author)
  • TcellSubC : An Atlas of the Subcellular Proteome of Human T Cells
  • 2019
  • In: Frontiers in Immunology. - : FRONTIERS MEDIA SA. - 1664-3224. ; 10
  • Journal article (peer-reviewed)abstract
    • We have curated an in-depth subcellular proteomic map of primary human CD4+ T cells, divided into cytosolic, nuclear and membrane fractions generated by an optimized fractionation and HiRIEF-LC-MS/MS workflow for limited amounts of primary cells. The subcellular proteome of T cells was mapped under steady state conditions, as well as upon 15 min and 1 h of T cell receptor (TCR) stimulation, respectively. We quantified the subcellular distribution of 6,572 proteins and identified a subset of 237 potentially translocating proteins, including both well-known examples and novel ones. Microscopic validation confirmed the localization of selected proteins with previously known and unknown localization, respectively. We further provide the data in an easy-to-use web platform to facilitate re-use, as the data can be relevant for basic research as well as for clinical exploitation of T cells as therapeutic targets.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Vesterlund, Mattias (1)
Lehtio, Janne (1)
Stadler, Charlotte (1)
Tegnér, Jesper (1)
Schmidt, Angelika (1)
Joshi, Rubin Narayan (1)
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Lehmann, Robert (1)
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University
Royal Institute of Technology (1)
Karolinska Institutet (1)
Language
English (1)
Research subject (UKÄ/SCB)
Natural sciences (1)
Year
2019 (1)

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