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  • Arewang, Carl Johan, et al. (author)
  • Synthesis of urine drug metabolites : glucuronic acid glycosides of phenol intermediates
  • 2007
  • In: Carbohydrate Research. - : Elsevier BV. - 0008-6215 .- 1873-426X. ; 342:7, s. 970-974
  • Journal article (peer-reviewed)abstract
    • The investigation of drug metabolism requires substantial amount of metabolites. Isolation from urine is tedious, therefore, the material obtained by synthesis is preferred. Substantial amounts of three tentative drug metabolites, phenolic glucuronides, have been prepared using easily available glycosyl donors. The final products [3(2-N-methyl-N-isopropylaminoethoxy)phenyl] beta-D-glucopyranosiduronic acid, 4-amino-3,5-dimethylphenyl beta-D-glucopyranosiduronic acid and [2(S)-propanoyl-6-O-naphthyl] beta-D-glucopyranuronic acid are useful as, for example, reference material in metabolite investigations.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Oscarson, Stefan (1)
Lahmann, Martina (1)
Arewang, Carl Johan (1)
Tiden, Anna-Karin (1)
University
Royal Institute of Technology (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2007 (1)

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