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  • Aili, Daniel, 1977-, et al. (author)
  • Controlled Assembly of Gold Nanoparticles using De Novo Designed Polypeptide Scaffolds
  • 2008
  • In: Proceedings SPIE, Vol. 6885, Photonic Biosensing and Microoptics. - : SPIE. ; , s. 688506-1-688506-8
  • Conference paper (peer-reviewed)abstract
    • Heterodimerization between designed helix-loop-helix polypeptides was utilized in order to assemble gold nanoparticles on planar substrates. The peptides were designed to fold into four-helix bundles upon dimerization. A Cys-residue in the loop region was used to immobilize one of the complementary peptides on a maleimide containing SAM on planar gold substrates whereas the second peptide was immobilized directly on gold nanoparticles. Introducing the peptide decorated particles over a peptide functionalized surface resulted in particle assembly. Further, citrate stabilized particles were assembled on amino-silane modified glass and silicon substrates. By subsequently introducing peptides and gold nanoparticles, particle-peptide hybrid multi layers could be formed.
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Type of publication
conference paper (1)
Type of content
peer-reviewed (1)
Author/Editor
Liedberg, Bo (1)
Aili, Daniel, 1977- (1)
Enander, Karin (1)
Rydberg, Johan (1)
Baltzer, Lars (1)
Nesterenko, Irina (1)
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Björefors, Fredrik (1)
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University
Linköping University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2008 (1)

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