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  • Blake, Jessie A, et al. (author)
  • Design of xanthone propionate photolabile protecting group releasing acyclovir for the treatment of ocular herpes simplex virus
  • 2012
  • In: Photochemical and Photobiological Sciences. - : Royal Society of Chemistry. - 1474-905X .- 1474-9092. ; 11:3, s. 539-547
  • Journal article (peer-reviewed)abstract
    • We have attached the antiviral drug acyclovir (ACV) to a xanthone photolabile protecting group (or photocage) through the O6 position of acyclovir, a procedure designed for the treatment of ocular herpes simplex virus infections. Acyclovir is photoreleased from the photocage, under physiological conditions, with a quantum yield (Phi(ACV release)) of 0.1-0.3 and an uncaging cross section (Phi.epsilon) of 450-1350 M cm(-1). We demonstrate that this photorelease method outcompetes alternative reaction pathways, such as protonation. Furthermore, complete release of the drug is theoretically possible given a sufficient dose of light. Surprisingly the acyclovir photocage, also showed some antiviral activity towards HSV-1.
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  • Result 1-1 of 1
Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Griffith, May (1)
Blake, Jessie A (1)
Bareiss, Bettina (1)
Jimenez, Liliana (1)
Scaiano, J C (1)
University
Linköping University (1)
Language
English (1)
Year
2012 (1)

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