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  • Nyesiga, Barnabas, et al. (author)
  • CD22 (CD22 molecule)
  • 2020
  • In: Atlas of Genetics and Cytogenetics in Oncology and Haematology. - : INIST-CNRS. - 1768-3262. ; :12
  • Research review (peer-reviewed)abstract
    • Sialic acid binding immunoglobulin-type lectin (Siglec) family are inhibitory receptors with diverse roles in the immune system. Siglec family contains 14 members in human and 9 in murine. Differentially expressed on various white blood cells. Here in this review we are focusing on CD22, also known as Sialic Acid-Binding Ig-Like Lectin 2 (Siglec-2). CD22 gene is located on 19q13.12 and is encoding a 140 kD type I transmembrane glycoprotein on the surface of B cells and is part of the immunoglobulin (Ig) superfamily and has been found only on B cells. CD22 has been shown to play a major role in establishing a baseline level of B-cell inhibition, and thus is a critical determinant of homeostasis in humoral immunity.
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  • Result 1-1 of 1
Type of publication
research review (1)
Type of content
peer-reviewed (1)
Author/Editor
El-Schich, Zahra (1)
Nyesiga, Barnabas (1)
University
Malmö University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Natural sciences (1)
Year
2020 (1)

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