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  • Davies, James S., et al. (author)
  • TRAPs : the 'elevator-with-an-operator' mechanism
  • 2024
  • In: Trends in Biochemical Sciences (TIBS). - 0968-0004 .- 1362-4326. ; 49:2, s. 134-144
  • Research review (peer-reviewed)abstract
    • Tripartite ATP -independent periplasmic (TRAP) transporters are nutrient -uptake systems found in bacteria and archaea. These evolutionary divergent transporter systems couple a substrate -binding protein (SBP) to an elevator -type secondary transporter, which is a first -of -its -kind mechanism of transport. Here, we highlight breakthrough TRAP transporter structures and recent functional data that probe the mechanism of transport. Furthermore, we discuss recent structural and biophysical studies of the ion transporter superfamily (ITS) members and highlight mechanistic principles that are relevant for further exploration of the TRAP transporter system.
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Type of publication
research review (1)
Type of content
peer-reviewed (1)
Author/Editor
North, Rachel A. (1)
Currie, Michael J. (1)
Davies, James S. (1)
Dobson, Renwick C. J ... (1)
Horne, Christopher R (1)
University
Stockholm University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Natural sciences (1)
Year
2024 (1)

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