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  • Björnberg, Olof, et al. (author)
  • Ribosylurea accumulates in yeast urc4 mutants
  • 2010
  • In: Nucleosides, Nucleotides & Nucleic Acids. - : Informa UK Limited. - 1525-7770 .- 1532-2335. ; 29:4-6, s. 433-437
  • Journal article (peer-reviewed)abstract
    • Yeast Saccharomyces (Lachancea) kluyveri urc4 mutants, unable to grow on uracil, biotransformed (14)C(2)-uracil into two labeled compounds, as detected by high performance liquid chromatography (HPLC). These two compounds could also be obtained following organic synthesis of ribosylurea. This finding demonstrates that in the URC pyrimidine degradation pathway, the opening of the uracil ring takes place when uracil is attached to the ribose moiety. Ribosylurea has not been reported in the cell metabolism before and the two observed compounds likely represent an equilibrium mixture of the pyranosyl and furanosyl forms.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Piskur, Jure (1)
Andersen, G. (1)
Björnberg, Olof (1)
Rasmussen, Anna (1)
Hofer, Anders (1)
Vodnala, Munender (1)
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Domkin, Vladimir (1)
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University
Umeå University (1)
Lund University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Natural sciences (1)
Medical and Health Sciences (1)
Year
2010 (1)

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