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  • Metzendorf, Christoph, et al. (author)
  • The role of iron in the proliferation of Drosophila l(2)mbn cells
  • 2010
  • In: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier BV. - 0006-291X .- 1090-2104. ; 400:3, s. 442-446
  • Journal article (peer-reviewed)abstract
    • Iron is essential for life and is needed for cell proliferation and cell cycle progression. Iron deprivation induces cell cycle arrest and finally apoptosis. The Drosophila tumorous larval hemocyte cell line l(2)mbn was used to study the sensitivity and cellular response to iron deprivation through the chelator desferrioxamine (DFO). At a concentration of 10 mM DFO or more the proliferation was inhibited reversibly, while the amount of dead cells did not increase. FACS analysis showed that the cell cycle was arrested in G1/S phase and the transcript level of cycE was decreased to less than 50% of control cells. These results show that iron chelation in this insect tumorous cell line causes a specific and coordinated cell cycle arrest.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Metzendorf, Christop ... (1)
Lind, Maria I (1)
University
Uppsala University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Natural sciences (1)
Year
2010 (1)

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