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  • Roggen, Heidi, et al. (author)
  • Antimicrobial and antineoplastic activities of Agelasine analogs modified in the purine 2-position
  • 2011
  • In: Archiv der Pharmazie. - : Wiley. - 0365-6233 .- 1521-4184. ; 344:1, s. 50-55
  • Journal article (peer-reviewed)abstract
    • Agelasines are 7,9-dialkylpurinium salts found in marine sponges (Agelas sp.), which display a variety of antimicrobial and cytotoxic effects. We have synthesized simplified agelasine analogs modified in the purine 2-position and examined their antimicrobial and anticancer activities. The compounds were screened against Staphylococcus aureus, Escherichia coli, Mycobacterium tuberculosis, Candida krusei, and Candida albicans, protozoa causing tropical diseases (Plasmodium falciparum, Leishmania infantum, Trypanosoma cruzi, and Trypanosoma brucei), a panel of human cancer cell lines (U-937 GTB, RPMI 8226/s, CEM/s, and ACHN) as well as VERO and/or MRC-5 cells. The results indicate that the introduction of a methyl group in the purine 2-position is beneficial for antimycobacterial and antiprotozoal activity, and that amino groups may enhance activity against several cancer cell lines.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Larsson, Rolf (1)
Burman, Robert (1)
Felth, Jenny (1)
Bohlin, Lars, 1948- (1)
Gundersen, Lise-Lott ... (1)
Charnock, Colin (1)
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Roggen, Heidi (1)
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University
Uppsala University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2011 (1)

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