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- Lövqvist, Anna, et al.
(author)
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76Br-labeled monoclonal anti-CEA antibodies for radioimmuno positron emission tomography
- 1995
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In: Nuclear Medicine and Biology. - 0969-8051 .- 1872-9614. ; 22:1, s. 125-131
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Journal article (peer-reviewed)abstract
- For the application of anti-tumor monoclonal antibodies (MAbs) in positron emission tomography (PET), labeling radionuclides with half-lives allowing a suitable time frame for imaging are required. The anti-CEA MAb 38S1 was labeled with the positron emitting nuclide 76Br (t1/2 16 h) using bromoperoxidase (BPO), and subsequently affinity purified. A procedure was devised to allow reproducible production of MAb-preparations of high immunoreactivity and with acceptable bromination yield. The biological activity of 76Br-38S1 was retained and comparable to that of chloramine-T labeled 125I-38S1, as tested in vitro.
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