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  • Naji, Latifa, et al. (author)
  • ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion
  • 2011
  • In: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier BV. - 0006-291X .- 1090-2104. ; 409:1, s. 96-102
  • Journal article (peer-reviewed)abstract
    • The atypical Rho GTPase Wrch-1 has been proposed roles in cell migration, focal adhesion dissolution, stress fibre break down and tight junction heterogeneity. A screen for Wrch-1 binding-partners identified the novel RhoGAP protein, ARHGAP30, as a Wrch-1 interactor. ARHGAP30 is related to the Cdc42- and Rac1-specific RhoGAP CdGAP, which was likewise found to bind Wrch-1. In contrast to CdGAP, ARHGAP30 serves as a Rac1- and RhoA-specific RhoGAP. Ectopic expression of ARHGAP30 results in membrane blebbing and dissolution of stress-fibres and focal adhesions. Our data suggest roles for ARHGAP30 and CdGAP in regulation of cell adhesion downstream of Wrch-1.
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  • Result 1-1 of 1
Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Aspenström, Pontus (1)
Pacholsky, Dirk (1)
Naji, Latifa (1)
University
Uppsala University (1)
Karolinska Institutet (1)
Language
English (1)
Year
2011 (1)

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