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  • Enblad, Gunilla, et al. (author)
  • The potential role of innate immunity in the pathogenesis of Hodgkin's lymphoma
  • 2007
  • In: Hematology/Oncology Clinics of North America. - : Elsevier BV. - 0889-8588 .- 1558-1977. ; 21:5, s. 805-823
  • Journal article (peer-reviewed)abstract
    • The innate immune system is our first line of defense against danger signals but in Hodgkin's lymphoma the role seems opposite, favoring malignant development. In this article we describe interactions between Hodgkin's and Reed-Sternberg cells and the cells of the innate immune system: eosinophils, mast cells, neutrophils, and macrophages. These cells clearly contribute to the pathogenesis of this disease and to the prognosis. Cytokines and chemokines released from the activated immune cells probably promote tumor cell growth and survival along with angiogenesis. Mast cells and eosinophils seem also to contribute to the fibrosis that is so characteristic for nodular sclerosis.
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  • Result 1-1 of 1
Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Molin, Daniel (1)
Enblad, Gunilla (1)
Nilsson, Gunnar (1)
Glimelius, Ingrid (1)
Fischer, Marie (1)
University
Uppsala University (1)
Karolinska Institutet (1)
Language
English (1)
Year
2007 (1)

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