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  • Azuaje, Jhonny, et al. (author)
  • Pyrazin-2(1H)-ones as a novel class of selective A3 adenosine receptor antagonists
  • 2015
  • In: Future Medicinal Chemistry. - : Future Science Ltd. - 1756-8919 .- 1756-8927. ; 7:11, s. 1373-1380
  • Journal article (peer-reviewed)abstract
    • Background: A(3)AR antagonists are promising drug candidates as neuroprotective agents as well as for the treatment of inflammation or glaucoma. The most widely known A(3)AR antagonists are derived from polyheteroaromatic scaffolds, which usually show poor pharmacokinetic properties. Accordingly, the identification of structurally simple A(3)AR antagonists by the exploration of novel diversity spaces is a challenging goal. Results: A convergent and efficient Ugi-based multicomponent approach enabled the discovery of pyrazin-2(1H)-ones as a novel class of A(3)AR antagonists. A combined experimental/computational strategy accelerated the establishment of the most salient features of the structure-activity and structure-selectivity relationships in this series. Conclusion: The optimization process provided pyrazin-2(1H)-ones with improved affinity and a plausible hypothesis regarding their binding modes was proposed.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Gutierrez-de-Teran, ... (1)
Azuaje, Jhonny (1)
Caamano, Olga (1)
Sotelo, Eddy (1)
Carbajales, Carlos (1)
Gonzalez-Gomez, Manu ... (1)
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Coelho, Alberto (1)
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University
Uppsala University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2015 (1)

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