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  • Enroth, Stefan, et al. (author)
  • Effect of genetic and environmental factors on protein biomarkers for common non-communicable disease and use of personally normalized plasma protein profiles (PNPPP)
  • 2015
  • In: Biomarkers. - 1354-750X .- 1366-5804. ; 20:6-7, s. 355-364
  • Journal article (peer-reviewed)abstract
    • Objective: To study the impact of genetic and lifestyle factors on protein biomarkers and develop personally normalized plasma protein profiles (PNPPP) controlling for non-disease-related variance.Materials and methods: Proximity extension assays were used to measure 145 proteins in 632 controls and 344 cases with non-communicable diseases.Results: Genetic and lifestyle factors explained 20-88% of the variation in healthy controls. Adjusting for these factors reduced the number of candidate biomarkers by 63%.Conclusion: PNPPP efficiently controls for non-disease-related variance, allowing both for efficient discovery of novel biomarkers and for covariate-independent linear cut-offs suitable for clinical use.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Enroth, Stefan (1)
Johansson, Åsa (1)
Gyllensten, Ulf (1)
Enroth, Sofia Bosdot ... (1)
University
Uppsala University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2015 (1)

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