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  • Gill, H S, et al. (author)
  • Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine.
  • 2010
  • In: Gene therapy. - : Springer Science and Business Media LLC. - 1476-5462 .- 0969-7128. ; 17:6, s. 811-814
  • Journal article (peer-reviewed)abstract
    • The skin is potentially an excellent organ for vaccine delivery because of accessibility and the presence of immune cells. However, no simple and inexpensive cutaneous vaccination method is available. Micron-scale needles coated with DNA were tested as a simple, inexpensive device for skin delivery. Vaccination with a plasmid encoding hepatitis C virus nonstructural 3/4A protein using microneedles effectively primed specific cytotoxic T lymphocytes (CTLs). Importantly, the minimally invasive microneedles were as efficient in priming CTLs as more complicated or invasive delivery techniques, such as gene gun and hypodermic needles. Thus, microneedles may offer a promising technology for DNA vaccination.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Sällberg, M (1)
Söderholm, Jonas, 19 ... (1)
Gill, H S (1)
Prausnitz, M R (1)
University
University of Gothenburg (1)
Karolinska Institutet (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2010 (1)

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