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  • Wang, Lei, et al. (author)
  • Linking DNA methylation to the onset of human tubal ectopic pregnancy.
  • 2013
  • In: American journal of translational research. - 1943-8141. ; 5:2, s. 116-25
  • Journal article (peer-reviewed)abstract
    • Ectopic pregnancy is a common reproductive disorder of unknown etiology and is a leading cause of maternal and fetal mortality. Because of the asymptomatic nature of early tubal ectopic pregnancy and the lack of specific biomarkers for early diagnosis, a better understanding of the complex cellular and molecular interactions that contribute to tubal ectopic pregnancy is required. DNA methylation is the most studied epigenetic process in various tissues and cells, and the goal of this article is to provide a brief review of recent work describing the potential mechanisms of DNA methylation and the biological function of such methylation in normal intrauterine pregnancy. Further, novel findings from our laboratory highlight the possible role of DNA methylation in human Fallopian tube dysfunction and suggest a possible correlation between methylation of estrogen receptor α in women and the occurrence of tubal ectopic pregnancies.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Wang, Lei (1)
Brännström, Mats, 19 ... (1)
Feng, Yi (1)
Billig, Håkan, 1955 (1)
Shao, Linus Ruijin, ... (1)
He, Lin (1)
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Zou, Shien (1)
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University
University of Gothenburg (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2013 (1)

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