SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "id:"swepub:oai:gup.ub.gu.se/195711" "

Search: id:"swepub:oai:gup.ub.gu.se/195711"

  • Result 1-1 of 1
Sort/group result
   
EnumerationReferenceCoverFind
1.
  • Scimemi, Annalisa, et al. (author)
  • Tonic GABA(A) receptor-mediated currents in human brain.
  • 2006
  • In: The European journal of neuroscience. - : Wiley. - 0953-816X .- 1460-9568. ; 24:4, s. 1157-60
  • Journal article (peer-reviewed)abstract
    • GABA(A) receptors can mediate both phasic (synaptic) and tonic (extrasynaptic) forms of inhibition. It has been proposed that tonic inhibition plays a critical part in controlling neuronal and network excitability. Although tonic GABA(A) receptor-mediated currents have been well characterized in rodents, their existence in human tissue has yet to be demonstrated. Here we show that tonic currents can be recorded from human tissue obtained from patients undergoing temporal lobectomies. Tonic GABA(A) receptor-mediated currents were present in pyramidal cells and interneurons in layer V-VI of temporal neocortex and granule cells in the dentate gyrus. These tonic currents have cell type-specific pharmacologies, opening up the possibility of targeted therapeutics.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-1 of 1

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view