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  • Biram, Adi, et al. (author)
  • B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches.
  • 2020
  • In: Cell reports. - : Elsevier BV. - 2211-1247. ; 30:6
  • Journal article (peer-reviewed)abstract
    • Antibodies secreted within the intestinal tract provide protection from the invasion of microbes into the host tissues. Germinal center (GC) formation in lymph nodes and spleen strictly requires SLAM-associated protein (SAP)-mediated Tcell functions; however, it is not known whether this mechanism plays a similar role in mucosal-associated lymphoid tissues. Here, we find that in Peyer's patches (PPs), SAP-mediated Tcell help is required for promoting B cell selection in GCs, but not for clonal diversification. PPs of SAP-deficient mice host chronic GCs that are absent in Tcell-deficient mice. GC B cells in SAP-deficient mice express AID and Bcl6 and generate plasma cellsin proportion to the GC size. Single-cell IgA sequencing analysis reveals that these mice host few diversified clones that were subjected to mild selection forces. These findings demonstrate that Tcell-derived help to B cells in PPs includes SAP-dependent and SAP-independent functions.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Bemark, Mats, 1967 (1)
Biram, Adi (1)
Winter, Eitan (1)
Denton, Alice E (1)
Zaretsky, Irina (1)
Dassa, Bareket (1)
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Linterman, Michelle ... (1)
Yaari, Gur (1)
Shulman, Ziv (1)
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University
University of Gothenburg (1)
Language
English (1)
Research subject (UKÄ/SCB)
Natural sciences (1)
Medical and Health Sciences (1)
Year
2020 (1)

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