SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "id:"swepub:oai:lup.lub.lu.se:5f3b5a9d-d7b1-43a5-a845-9ac2fa301793" "

Search: id:"swepub:oai:lup.lub.lu.se:5f3b5a9d-d7b1-43a5-a845-9ac2fa301793"

  • Result 1-1 of 1
Sort/group result
   
EnumerationReferenceCoverFind
1.
  • Gebe, John A, et al. (author)
  • Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice.
  • 2006
  • In: Clinical Immunology. - : Elsevier BV. - 1521-6616. ; 121:3, s. 294-304
  • Journal article (peer-reviewed)abstract
    • We have identified for the first time an age-dependent spontaneous loss of tolerance to two self-antigenic epitopes derived from putative diabetes-associated antigens glutamic acid decarboxylase (GAD65) and glial fibrillary acidic protein (GFAP) in RIP-B7/DRB1*0404 HLA transgenic mice. Diabetic and older non-diabetic mice exhibited a proliferative response to an immunodominant epitope from GAD65 (555-567) and also from GFAP (240-252) but not from an immunogenic epitope from diabetes-associated islet-specific glucose-6-phosphatase catalytic subunit-related protein. The response to both of these self-antigens is not observed in young mice but is observed in older non-diabetic mice and is accompanied by histological evidence of insulitis in the absence of overt diabetes. Islet infiltrates in older non-diabetic mice and diabetic mice contain CD4(+)/FoxP3(+) cells and suggest the presence of a regulatory mechanism prior and during diabetic disease. Diabetes penetrance in RIP-B7/DR0404 mice
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-1 of 1
Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Lernmark, Åke (1)
Gebe, John A (1)
Unrath, Kellee A (1)
Falk, Ben A (1)
Kouichi, Ito (1)
Wen, Li (1)
show more...
Daniels, Terri L (1)
Nepom, Gerald T (1)
show less...
University
Lund University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2006 (1)

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view