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  • Bergkvist, My, et al. (author)
  • No evidence for genetic linkage between development of multiple sclerosis and components of the IFN system and the JAK-STAT pathway.
  • 2004
  • In: Multiple Sclerosis Journal. - : SAGE Publications. - 1477-0970 .- 1352-4585. ; 10:1, s. 87-88
  • Journal article (peer-reviewed)abstract
    • Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system (CNS). Several observations suggest that the interferon system may be of interest in the study of MS development. To investigate whether polymorphism in components of the IFN system and the JA K-STAT pathway influence susceptibility to MS, we performed a linkage analysis between polymorphic loci in or close to the IFN gamma, IFN gamma recepto r, IFN alpha/beta recepto r, JA K 1, STAT 1 and STAT 3 genes in 27 Swedish families with at least two members having MS. Tests for transmission disequilibrium and nonparametric linkage analysis gave negative results. We found no evidence for linkage between MS and any of these loci.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Olsson, M. (1)
Sandberg Wollheim, M ... (1)
Bergkvist, My (1)
University
Lund University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
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