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  • Ogura, Y, et al. (author)
  • An international meta-analysis confirms the association of BNC2 with adolescent idiopathic scoliosis
  • 2018
  • In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8:1, s. 4730-
  • Journal article (peer-reviewed)abstract
    • Adolescent idiopathic scoliosis (AIS) is a common spinal deformity with the prevalence of approximately 3%. We previously conducted a genome-wide association study (GWAS) using a Japanese cohort and identified a novel locus on chromosome 9p22.2. However, a replication study using multi-population cohorts has not been conducted. To confirm the association of 9p22.2 locus with AIS in multi-ethnic populations, we conducted international meta-analysis using eight cohorts. In total, we analyzed 8,756 cases and 27,822 controls. The analysis showed a convincing evidence of association between rs3904778 and AIS. Seven out of eight cohorts had significant P value, and remaining one cohort also had the same trend as the seven. The combined P was 3.28 × 10−18 (odds ratio = 1.19, 95% confidence interval = 1.14–1.24). In silico analyses suggested that BNC2 is the AIS susceptibility gene in this locus.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Takahashi, Y. (1)
Watanabe, K. (1)
Zhou, H. (1)
Einarsdottir, E (1)
Kere, J (1)
Wu, N. (1)
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Liu, G (1)
Gerdhem, P (1)
Qiu, Y. (1)
Ikegawa, S (1)
Wu, ZH (1)
Matsumoto, M. (1)
Takeda, K (1)
Huang, DS (1)
Grauers, A (1)
Kou, I. (1)
Fan, YH (1)
Wise, CA (1)
Song, YQ (1)
Ogura, Y. (1)
Khanshour, A (1)
Zhou, TF (1)
Qiu, GX (1)
Su, PQ (1)
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University
Karolinska Institutet (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2018 (1)

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