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- Arafa, Wael Abdelgayed Ahmed, et al.
(author)
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An eco-compatible access to diversified bisoxazolone and bisimidazole derivatives
- 2018
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In: ARKIVOC. - : Arkat. - 1551-7004 .- 1551-7012. ; , s. 338-353
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Journal article (peer-reviewed)abstract
- An efficient, straight-forward and eco-friendly synthetic strategy for the assembly of novel bisoxazolones via a four-component, sequential reaction of dialdehydes, glycine, benzoyl chloride and acetic anhydride, using ultrasound radiation, is described. Additionally, a diverse group of new bisimidazoles has been synthesized in good yields by the sonication of diamines and (Z)-4-arylidene-2-phenyloxazol-5(4H)-ones. These approaches have resulted in a number of successful routes for the facile synthesis of bis-oxazolone and bis-imidazole frameworks within minutes of irradiation. Excellent outcomes using these environmentally-friendly parameters make these synthetic schemes ideal, sustainable, green-chemistry procedures and provide simple access towards the preparation of bisheterocycles. [GRAPHICS] .
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