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  • Uhlén, Mathias, et al. (author)
  • Sequential sequencing by synthesis and the next-generation sequencing revolution
  • 2023
  • In: Trends in Biotechnology. - : Elsevier BV. - 0167-7799 .- 1879-3096. ; 41:12, s. 1565-1572
  • Research review (peer-reviewed)abstract
    • The impact of next-generation sequencing (NGS) cannot be overestimated. The technology has transformed the field of life science, contributing to a dramatic expansion in our understanding of human health and disease and our understanding of biology and ecology. The vast majority of the major NGS systems today are based on the concept of 'sequencing by synthesis' (SBS) with sequential detection of nucleotide incorporation using an engineered DNA polymerase. Based on this strategy, various alternative platforms have been developed, including the use of either native nucleotides or reversible terminators and different strategies for the attachment of DNA to a solid support. In this review, some of the key concepts leading to this remarkable development are discussed.
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Type of publication
research review (1)
Type of content
peer-reviewed (1)
Author/Editor
Uhlén, Mathias (1)
Quake, Stephen R. (1)
University
Royal Institute of Technology (1)
Karolinska Institutet (1)
Language
English (1)
Research subject (UKÄ/SCB)
Natural sciences (1)
Year
2023 (1)

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