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  • Strömberg, Ingrid, et al. (author)
  • c-fos antisense oligonucleotides increase firing rate of striatal neurons in the anaesthetized rat.
  • 2004
  • In: Brain Research. - : Elsevier BV. - 0006-8993. ; 1000:1-2, s. 192-4
  • Journal article (peer-reviewed)abstract
    • Extracellular electrophysiological recordings were used to study the firing rate of striatal neurons before and up to 4 h after intrastriatal c-fos antisense oligonucleotide injections in urethane-anesthetized rats. A four-fold increase from baseline neuronal activity was observed between 1 and 3 h upon antisense treatment, but not after control oligonucleotide injections. We conclude that, under urethane anesthesia, which here does not affect c-fos expression in the striatum by itself, neuronal activity appears to be tonically suppressed by basal striatal c-fos expression.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Strömberg, Ingrid (1)
Hansson, Anita C (1)
Sommer, Wolfgang (1)
Rimondini, Roberto (1)
Stromberg, F (1)
University
Umeå University (1)
Karolinska Institutet (1)
Language
English (1)
Year
2004 (1)

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