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  • Farkas, Sanja A., 1983-, et al. (author)
  • Epigenetic changes as prognostic predictors in endometrial carcinomas
  • 2017
  • In: Epigenetics. - : Informa UK Limited. - 1559-2294 .- 1559-2308. ; 12:1, s. 19-26
  • Journal article (peer-reviewed)abstract
    • Endometrial carcinoma is one of the most frequent gynecological malignancies of the female. The diagnostic and prognostic markers for the high-risk subgroups with unfavorable prognosis are under intense debate worldwide, and, therefore, the aim of this study was to identify new potential DNA methylation markers for the high-risk groups. We used the Illumina Infinium HumanMethylation450 BeadChip to analyze the DNA methylation pattern and investigated its association with clinicopathological features important for defining the high-risk (FIGO-grade 3) and low-risk (FIGO-grade 1) groups of patients with endometrial cancer (n = 31 and n = 39, respectively). We identified specific DNA methylation signature in high-risk endometrial tumors, and potential molecular biomarker genes (TBX2, CHST11, and NID2) associated with unfavorable clinical predictive and prognostic factors.
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  • Result 1-1 of 1
Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Nilsson, Torbjörn K (1)
Farkas, Sanja A., 19 ... (1)
Sorbe, Bengt G., 194 ... (1)
University
Umeå University (1)
Örebro University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Natural sciences (1)
Medical and Health Sciences (1)
Year
2017 (1)

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