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  • Pettersson, Mats, et al. (author)
  • Capacitating epistasis--detection and role in the genetic architecture of complex traits.
  • 2015
  • In: Methods in Molecular Biology. - New York, NY : Springer New York. - 1064-3745 .- 1940-6029. ; 1253:1253, s. 185-196
  • Journal article (peer-reviewed)abstract
    • Here, we discuss the potential role of capacitating epistasis in the genetic architecture of complex traits. Two alternative methods for identifying such gene-gene interactions in genetic association studies-mapping of variance controlling loci and the variance plane ratio (VPR) method-are introduced. An overview of the theoretical foundation of the methods is presented together with a discussion on their implementation and available software for performing these analyses. We conclude by highlighting a few examples of capacitating epistasis described in the literature and its potential impacts on the genetics of complex traits.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Pettersson, Mats (1)
Carlborg, Örjan (1)
University
Uppsala University (1)
Swedish University of Agricultural Sciences (1)
Language
English (1)
Research subject (UKÄ/SCB)
Natural sciences (1)
Year
2015 (1)

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