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  • Fagman, Henrik, 1975, et al. (author)
  • Morphogenetics of early thyroid development.
  • 2010
  • In: Journal of molecular endocrinology. - 1479-6813.
  • Research review (peer-reviewed)abstract
    • The thyroid develops from the foregut endoderm. Yet uncharacterized inductive signals specify endoderm progenitors to a thyroid cell fate that assemble in the pharyngeal floor from which the primordium buds and migrates to the final position of the gland. The morphogenetic process is regulated by both cell-autonomous (activated by e.g. Nkx2-1, Foxe1, Pax8 and Hhex) and mesoderm-derived (mediated by e.g. Tbx1 and Fgf) mechanisms acting in concert to promote growth and survival of progenitor cells. The developmental role of thyroid-stimulating hormone is limited to thyroid differentiation set to work after the gross anatomy of the gland is already sculptured. This review summarizes recent advances on the molecular genetics of thyroid morphogenesis put into context of endoderm developmental traits and highlights established and potentially novel mechanisms of thyroid dysgenesis of relevance to congenital hypothyroidism in man.
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Type of publication
research review (1)
Type of content
peer-reviewed (1)
Author/Editor
Nilsson, Mikael (1)
Fagman, Henrik, 1975 (1)
University
University of Gothenburg (1)
Language
English (1)
Research subject (UKÄ/SCB)
Natural sciences (1)
Medical and Health Sciences (1)
Year
2010 (1)

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