SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "onr:"swepub:oai:lup.lub.lu.se:a529f66f-596d-4cd9-b435-77b605daa6aa" "

Search: onr:"swepub:oai:lup.lub.lu.se:a529f66f-596d-4cd9-b435-77b605daa6aa"

  • Result 1-1 of 1
Sort/group result
   
EnumerationReferenceCoverFind
1.
  • Björck, Lars, et al. (author)
  • Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus
  • 1990
  • In: Journal of Virology. - 0022-538X. ; 64:2, s. 941-943
  • Journal article (peer-reviewed)abstract
    • Cystatin C is a human cysteine proteinase inhibitor present in extracellular fluids. Cystatin C and a tripeptide derivative (Z-LVG-CHN2) that mimics its proteinase-binding center, were tested for possible antiviral activity against herpes simplex virus type 1 (HSV) and poliovirus type 1. Both recombinant cystatin C and Z-LVG-CHN2 displayed strong inhibitory effects on HSV replication, whereas no significant effect on poliovirus replication was seen. The molar concentration of cystatin C that gave total inhibition of HSV replication was lower than that of either Z-LVG-CHN2 or of acyclovir, the drug currently most used against HSV infections. These results suggest that cysteine proteinase inhibitors might play a physiological role as inhibitors of viral replication and that such proteinase inhibitors, or peptide derivatives that mimic their proteinase-binding centers, might be used as antiviral agents.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-1 of 1
Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Grubb, Anders (1)
Björck, Lars (1)
Kjellén, Lars (1)
University
Lund University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
1990 (1)

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view