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11.	Kanoni, Stavroula, et al. (author) Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. 2022 In: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1 Journal article (peer-reviewed)abstract Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N=1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
12.	Lindblad-Toh, Kerstin, et al. (author) Genome sequence, comparative analysis and haplotype structure of the domestic dog. 2005 In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 438:7069, s. 803-19 Journal article (peer-reviewed)abstract Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.
13.	Kanai, M, et al. (author) 2023 swepub:Mat__t
14.	Aad, G., et al. (author) A search for t (t)over-bar resonances with the ATLAS detector in 2.05 fb(-1) of proton-proton collisions at root s=7 TeV 2012 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 72:7 Journal article (peer-reviewed)
15.	Aad, G., et al. (author) ATLAS measurements of the properties of jets for boosted particle searches 2012 In: Physical Review D (Particles, Fields, Gravitation and Cosmology). - 1550-2368 .- 1550-7998. ; 86:7 Journal article (peer-reviewed)
16.	Aad, G., et al. (author) Combined search for the Standard Model Higgs boson in pp collisions at root s=7 TeV with the ATLAS detector 2012 In: Physical Review D (Particles, Fields, Gravitation and Cosmology). - 1550-2368 .- 1550-7998. ; 86:3 Journal article (peer-reviewed)
17.	Aad, G, et al. (author) Evidence for Electroweak Production of W^{±}W^{±}jj in pp Collisions at sqrt[s]=8 TeV with the ATLAS Detector. 2014 In: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 113:14 Journal article (peer-reviewed)
18.	Aad, G., et al. (author) Evidence for the associated production of a W boson and a top quark in ATLAS at root s=7 TeV 2012 Journal article (peer-reviewed)
19.	Aad, G., et al. (author) Evidence for the spin-0 nature of the Higgs boson using ATLAS data 2013 Journal article (peer-reviewed)
20.	Aad, G., et al. (author) Measurement of event shapes at large momentum transfer with the ATLAS detector in pp collisions at root s=7 TeV 2012 In: The European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6052. ; 72:11 Journal article (peer-reviewed)

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Type of publication: journal article (401); conference paper (4); reports (3); research review (3); other publication (1)

Type of content: peer-reviewed (452); other academic/artistic (5)

Author/Editor: Yang, Y. (354); Hughes, G. (353); Wang, J. (353); Chen, C. (352); Chen, H. (352); Francis, D. (352); show more...; Li, B. (352); Li, H. (352); Walker, R. (352); Wilson, A. (352); Asai, S. (351); Barklow, T. (351); Bella, G. (351); Benekos, N. (351); Bugge, L. (351); Chen, S. (351); Cowan, G. (351); Cranmer, K. (351); Davies, M. (351); Eigen, G. (351); Elsing, M. (351); Etzion, E. (351); Ferrer, A. (351); Fleck, I. (351); Gross, E. (351); Kawagoe, K. (351); Liebig, W. (351); Lucotte, A. (351); Martinez, M. (351); Mohr, W. (351); Morii, M. (351); Nagai, K. (351); Oh, A. (351); Ouraou, A. (351); Pallin, D. (351); Quadt, A. (351); Rembser, C. (351); Ros, E. (351); Salt, J. (351); Stugu, B. (351); Tanaka, R. (351); Tanaka, S. (351); Tarem, S. (351); Tasevsky, M. (351); Trefzger, T. (351); Ueda, I. (351); Vachon, B. (351); Vlachos, S. (351); Vrba, V. (351); Wengler, T. (351); show less...

University: Lund University (326); Uppsala University (316); Stockholm University (314); Royal Institute of Technology (287); Karolinska Institutet (33); University of Gothenburg (15); show more...; Umeå University (13); Chalmers University of Technology (7); Linköping University (4); RISE (3); Högskolan Dalarna (3); Swedish University of Agricultural Sciences (3); Halmstad University (2); Mid Sweden University (2); Marie Cederschiöld högskola (2); University West (1); Malmö University (1); Stockholm School of Economics (1); Swedish Environmental Protection Agency (1); Linnaeus University (1); Karlstad University (1); IVL Swedish Environmental Research Institute (1); show less...

Language: English (460); Swedish (2)

Research subject (UKÄ/SCB): Natural sciences (353); Medical and Health Sciences (40); Social Sciences (6); Engineering and Technology (5); Agricultural Sciences (1); Humanities (1)

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