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11.	Carlsson, Sven, et al. (author) Decision Support in Turbulent and High Velocity Environments 2008 In: Handbook on Decision Support Systems, Volume 2: Variations. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 9783540487159 ; , s. 3-17 Book chapter (other academic/artistic)
12.	Tyekucheva, Svitlana, et al. (author) Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer 2017 In: Nature Communications. - London, United Kingdom : Nature Publishing Group. - 2041-1723. ; 8:1 Journal article (peer-reviewed)abstract While progression from normal prostatic epithelium to invasive cancer is driven by molecular alterations, tumor cells and cells in the cancer microenvironment are co-dependent and co-evolve. Few human studies to date have focused on stroma. Here, we performed gene expression profiling of laser capture microdissected normal non-neoplastic prostate epithelial tissue and compared it to non-transformed and neoplastic low-grade and high-grade prostate epithelial tissue from radical prostatectomies, each with its immediately surrounding stroma. Whereas benign epithelium in prostates with and without tumor were similar in gene expression space, stroma away from tumor was significantly different from that in prostates without cancer. A stromal gene signature reflecting bone remodeling and immune-related pathways was upregulated in high compared to low-Gleason grade cases. In validation data, the signature discriminated cases that developed metastasis from those that did not. These data suggest that the microenvironment may influence prostate cancer initiation, maintenance, and metastatic progression.Stromal cells contribute to tumor development but the mechanisms regulating this process are still unclear. Here the authors analyze gene expression profiles in the prostate and show that stromal gene signature changes ahead of the epithelial gene signature as prostate cancer initiates and progresses.

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Type of publication: journal article (10); research review (1); book chapter (1)

Type of content: peer-reviewed (10); other academic/artistic (2)

Author/Editor: Franke, Barbara (4); Bai, Y. (3); Brown, J. (3); Chen, C. (3); Chen, H. (3); Chen, S. (3); show more...; Francis, D. (3); Huang, Y. (3); Li, B. (3); Li, H. (3); Liu, B. (3); Liu, M. (3); Liu, Y. (3); March, L. (3); Pinder, A. (3); Sanchez, A. (3); Silva, J. (3); Walker, R. (3); Wang, F. (3); Wang, J. (3); Webb, S. (3); White, S. (3); Williams, S. (3); Wilson, A. (3); Xu, L. (3); Yang, Y. (3); Zhang, H. (3); Zhang, J. (3); Zhang, L. (3); Zhu, Y. (3); Brenner, L. (3); Simon, D. (3); Zhou, C. (3); Brown, G. (3); Ellis, K. (3); Rose, A. (3); Zhao, L. (3); Ahmad, A. (3); He, M. (3); Ryan, P. (3); Schmitz, M. (3); Zhao, T. (3); Gupta, A. (3); Joseph, J. (3); Kennedy, J. (3); Li, J. (3); Yuan, J. (3); Zhang, Q. (3); Ren, Y. (3); Martin, J. (3); show less...

University: Karolinska Institutet (7); Uppsala University (4); Umeå University (3); University of Gothenburg (2); Lund University (2); Stockholm University (1); show more...; Örebro University (1); Linköping University (1); Stockholm School of Economics (1); show less...

Language: English (12)

Research subject (UKÄ/SCB): Medical and Health Sciences (10); Natural sciences (2); Social Sciences (2)

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